Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease. This study shows how different types of Aβ42 aggregates are associated with distinct mechanisms of toxicity

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Autores principales:	Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A. Aprile, Francesco S. Ruggeri, Daniel R. Whiten, Derya Emin, Zengjie Xia, Juan A. Varela, Pietro Sormanni, Franziska Kundel, Tuomas P. J. Knowles, Christopher M. Dobson, Clare Bryant, Michele Vendruscolo, David Klenerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dda94a3ed6064b0ba41892597f9160ae
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spelling	oai:doaj.org-article:dda94a3ed6064b0ba41892597f9160ae2021-12-02T14:38:59ZDifferent soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms10.1038/s41467-019-09477-32041-1723https://doaj.org/article/dda94a3ed6064b0ba41892597f9160ae2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09477-3https://doaj.org/toc/2041-1723Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease. This study shows how different types of Aβ42 aggregates are associated with distinct mechanisms of toxicitySuman DeDavid C. WirthensohnPatrick FlagmeierCraig HughesFrancesco A. AprileFrancesco S. RuggeriDaniel R. WhitenDerya EminZengjie XiaJuan A. VarelaPietro SormanniFranziska KundelTuomas P. J. KnowlesChristopher M. DobsonClare BryantMichele VendruscoloDavid KlenermanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suman De David C. Wirthensohn Patrick Flagmeier Craig Hughes Francesco A. Aprile Francesco S. Ruggeri Daniel R. Whiten Derya Emin Zengjie Xia Juan A. Varela Pietro Sormanni Franziska Kundel Tuomas P. J. Knowles Christopher M. Dobson Clare Bryant Michele Vendruscolo David Klenerman Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
description	Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease. This study shows how different types of Aβ42 aggregates are associated with distinct mechanisms of toxicity
format	article
author	Suman De David C. Wirthensohn Patrick Flagmeier Craig Hughes Francesco A. Aprile Francesco S. Ruggeri Daniel R. Whiten Derya Emin Zengjie Xia Juan A. Varela Pietro Sormanni Franziska Kundel Tuomas P. J. Knowles Christopher M. Dobson Clare Bryant Michele Vendruscolo David Klenerman
author_facet	Suman De David C. Wirthensohn Patrick Flagmeier Craig Hughes Francesco A. Aprile Francesco S. Ruggeri Daniel R. Whiten Derya Emin Zengjie Xia Juan A. Varela Pietro Sormanni Franziska Kundel Tuomas P. J. Knowles Christopher M. Dobson Clare Bryant Michele Vendruscolo David Klenerman
author_sort	Suman De
title	Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
title_short	Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
title_full	Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
title_fullStr	Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
title_full_unstemmed	Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
title_sort	different soluble aggregates of aβ42 can give rise to cellular toxicity through different mechanisms
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dda94a3ed6064b0ba41892597f9160ae
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Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

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