KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.

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Autores principales:	Mel Campbell, Tadashi Watanabe, Kazushi Nakano, Ryan R. Davis, Yuanzhi Lyu, Clifford G. Tepper, Blythe Durbin-Johnson, Masahiro Fujimuro, Yoshihiro Izumiya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dda9944922624a1d8b1fe07d7ee176f6
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spelling	oai:doaj.org-article:dda9944922624a1d8b1fe07d7ee176f62021-12-02T17:32:17ZKSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation10.1038/s41467-017-02089-92041-1723https://doaj.org/article/dda9944922624a1d8b1fe07d7ee176f62018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02089-9https://doaj.org/toc/2041-1723Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.Mel CampbellTadashi WatanabeKazushi NakanoRyan R. DavisYuanzhi LyuClifford G. TepperBlythe Durbin-JohnsonMasahiro FujimuroYoshihiro IzumiyaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mel Campbell Tadashi Watanabe Kazushi Nakano Ryan R. Davis Yuanzhi Lyu Clifford G. Tepper Blythe Durbin-Johnson Masahiro Fujimuro Yoshihiro Izumiya KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
description	Genomic loops and their temporal dynamics play an important role in gene expression of DNA viruses, but are incompletely understood. Here, the authors use capture Hi-C analyses and identify genomic architectural dynamics of KSHV that are regulated by the viral transactivator K-Rta.
format	article
author	Mel Campbell Tadashi Watanabe Kazushi Nakano Ryan R. Davis Yuanzhi Lyu Clifford G. Tepper Blythe Durbin-Johnson Masahiro Fujimuro Yoshihiro Izumiya
author_facet	Mel Campbell Tadashi Watanabe Kazushi Nakano Ryan R. Davis Yuanzhi Lyu Clifford G. Tepper Blythe Durbin-Johnson Masahiro Fujimuro Yoshihiro Izumiya
author_sort	Mel Campbell
title	KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_short	KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_full	KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_fullStr	KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_full_unstemmed	KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
title_sort	kshv episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dda9944922624a1d8b1fe07d7ee176f6
work_keys_str_mv	AT melcampbell kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT tadashiwatanabe kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT kazushinakano kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT ryanrdavis kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT yuanzhilyu kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT cliffordgtepper kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT blythedurbinjohnson kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT masahirofujimuro kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation AT yoshihiroizumiya kshvepisomesrevealdynamicchromatinloopformationwithdomainspecificgeneregulation
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KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation

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