Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence

Introduction: The efficacy of the applied model of laryngeal cancer treatment is measured by recurrence. Recurrence significantly reduces survival and determines the type of subsequent treatment. Objective: To determine the incidence of laryngeal cancer recurrence, the location of recurrence, and th...

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Autores principales:	Gašić Jugoslav, Jović Rajko, Vučinić Zmajko
Formato:	article
Lenguaje:	EN SR
Publicado:	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva 2021
Materias:	recurrence larynx cancer Medicine R
Acceso en línea:	https://doaj.org/article/ddaac27c358e4454b1a0c171b6af283b
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spelling	oai:doaj.org-article:ddaac27c358e4454b1a0c171b6af283b2021-12-05T21:29:52ZAnalysis of the occurrence, location and treatment of laryngeal carcinoma recurrence0350-87732560-331010.5937/pramed2102007Ghttps://doaj.org/article/ddaac27c358e4454b1a0c171b6af283b2021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2021/0350-87732101007G.pdfhttps://doaj.org/toc/0350-8773https://doaj.org/toc/2560-3310Introduction: The efficacy of the applied model of laryngeal cancer treatment is measured by recurrence. Recurrence significantly reduces survival and determines the type of subsequent treatment. Objective: To determine the incidence of laryngeal cancer recurrence, the location of recurrence, and the definitive treatment of laryngeal cancer recurrence concerning different types of surgical treatments applied. Results: In the period from 2002 to 2017, 844 subjects with primary operated laryngeal squamous cell carcinoma were analyzed. Recurrence developed in 191/844 (22.6%) subjects. The mean recurrence time is 12.6 months. Supraglottic carcinoma is more likely to recur than glottic carcinoma 35.93% / 17.46%, p = 0.000. In N0 necks the recurrence rate is 14.42% and in N + necks it is 45.91, p = 0.000. In more advanced stages of the disease, the number of recurrence increases, p = 0.000. The most common area of recurrence is the neck with 45%, followed by local recurrence with 25.1%. Recurrence most often occurs in subjects with total laryngectomy and partial pharyngectomy, 50%. The most common development of regional recurrence is in the N3 category and extracapsular spread, 72.7%. The definitive treatment of recurrence usually involves radical neck dissection and total laryngectomy. Subjects with recurrence have a significantly lower three-year overall survival compared to those without recurrence, 47.6% / 92.3%, p = 0.000. Conclusion: Recurrence is expected in every fourth patient in the first 36 months following any type of surgical treatment of laryngeal carcinoma. The efficacy of treatment is directly related to recurrence. Recurrence is more common in more advanced stages of disease, extracapsular spread, and present metastases in the neck. Recurrence significantly reduces the overall survival of patients with laryngeal cancer.Gašić JugoslavJović RajkoVučinić ZmajkoMedicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društvaarticlerecurrencelarynxcancerMedicineRENSRPraxis Medica, Vol 50, Iss 1-2, Pp 7-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	recurrence larynx cancer Medicine R
spellingShingle	recurrence larynx cancer Medicine R Gašić Jugoslav Jović Rajko Vučinić Zmajko Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
description	Introduction: The efficacy of the applied model of laryngeal cancer treatment is measured by recurrence. Recurrence significantly reduces survival and determines the type of subsequent treatment. Objective: To determine the incidence of laryngeal cancer recurrence, the location of recurrence, and the definitive treatment of laryngeal cancer recurrence concerning different types of surgical treatments applied. Results: In the period from 2002 to 2017, 844 subjects with primary operated laryngeal squamous cell carcinoma were analyzed. Recurrence developed in 191/844 (22.6%) subjects. The mean recurrence time is 12.6 months. Supraglottic carcinoma is more likely to recur than glottic carcinoma 35.93% / 17.46%, p = 0.000. In N0 necks the recurrence rate is 14.42% and in N + necks it is 45.91, p = 0.000. In more advanced stages of the disease, the number of recurrence increases, p = 0.000. The most common area of recurrence is the neck with 45%, followed by local recurrence with 25.1%. Recurrence most often occurs in subjects with total laryngectomy and partial pharyngectomy, 50%. The most common development of regional recurrence is in the N3 category and extracapsular spread, 72.7%. The definitive treatment of recurrence usually involves radical neck dissection and total laryngectomy. Subjects with recurrence have a significantly lower three-year overall survival compared to those without recurrence, 47.6% / 92.3%, p = 0.000. Conclusion: Recurrence is expected in every fourth patient in the first 36 months following any type of surgical treatment of laryngeal carcinoma. The efficacy of treatment is directly related to recurrence. Recurrence is more common in more advanced stages of disease, extracapsular spread, and present metastases in the neck. Recurrence significantly reduces the overall survival of patients with laryngeal cancer.
format	article
author	Gašić Jugoslav Jović Rajko Vučinić Zmajko
author_facet	Gašić Jugoslav Jović Rajko Vučinić Zmajko
author_sort	Gašić Jugoslav
title	Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
title_short	Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
title_full	Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
title_fullStr	Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
title_full_unstemmed	Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
title_sort	analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence
publisher	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
publishDate	2021
url	https://doaj.org/article/ddaac27c358e4454b1a0c171b6af283b
work_keys_str_mv	AT gasicjugoslav analysisoftheoccurrencelocationandtreatmentoflaryngealcarcinomarecurrence AT jovicrajko analysisoftheoccurrencelocationandtreatmentoflaryngealcarcinomarecurrence AT vuciniczmajko analysisoftheoccurrencelocationandtreatmentoflaryngealcarcinomarecurrence
_version_	1718370976071155712

Analysis of the occurrence, location and treatment of laryngeal carcinoma recurrence

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