Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice

Abstract Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastogr...

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Autores principales:	Vyacheslav A. Korshunov, Hexuan Wang, Rifat Ahmed, Deanne M. Mickelsen, Qian Zhou, Chen Yan, Marvin M. Doyley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ddab839bcc54458897dca5ab3f3d9b81
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spelling	oai:doaj.org-article:ddab839bcc54458897dca5ab3f3d9b812021-12-02T11:40:30ZModel-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice10.1038/s41598-017-12321-72045-2322https://doaj.org/article/ddab839bcc54458897dca5ab3f3d9b812017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12321-7https://doaj.org/toc/2045-2322Abstract Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young’s modulus was measured based on displacements of the carotid artery wall, and Young’s modulus was 2-fold greater in shams at 1 week post ligation, and 3-fold greater 2 weeks after ligation. Finally, the higher Young’s modulus was most associated with higher intimal thickness but not medial or adventitial thickness as measured by histology. In conclusion, we developed a robust ultrasound-based elastography method for early detection of intimal changes in small animals.Vyacheslav A. KorshunovHexuan WangRifat AhmedDeanne M. MickelsenQian ZhouChen YanMarvin M. DoyleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vyacheslav A. Korshunov Hexuan Wang Rifat Ahmed Deanne M. Mickelsen Qian Zhou Chen Yan Marvin M. Doyley Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
description	Abstract Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young’s modulus was measured based on displacements of the carotid artery wall, and Young’s modulus was 2-fold greater in shams at 1 week post ligation, and 3-fold greater 2 weeks after ligation. Finally, the higher Young’s modulus was most associated with higher intimal thickness but not medial or adventitial thickness as measured by histology. In conclusion, we developed a robust ultrasound-based elastography method for early detection of intimal changes in small animals.
format	article
author	Vyacheslav A. Korshunov Hexuan Wang Rifat Ahmed Deanne M. Mickelsen Qian Zhou Chen Yan Marvin M. Doyley
author_facet	Vyacheslav A. Korshunov Hexuan Wang Rifat Ahmed Deanne M. Mickelsen Qian Zhou Chen Yan Marvin M. Doyley
author_sort	Vyacheslav A. Korshunov
title	Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
title_short	Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
title_full	Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
title_fullStr	Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
title_full_unstemmed	Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
title_sort	model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ddab839bcc54458897dca5ab3f3d9b81
work_keys_str_mv	AT vyacheslavakorshunov modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT hexuanwang modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT rifatahmed modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT deannemmickelsen modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT qianzhou modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT chenyan modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice AT marvinmdoyley modelbasedvascularelastographyimprovesthedetectionofflowinducedcarotidarteryremodelinginmice
_version_	1718395612610691072

Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice

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