The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study

Background Diabetes mellitus (DM) is common among patients with schizophrenia. However, information on patients comorbid DM and schizophrenia is limited in China. The present study investigated the prevalence of DM and its clinical characteristics in Chinese inpatients with chronic schizophrenia. Me...

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Autores principales:	Yanni Wang, Lingyun Zeng, Lijuan Chen, Xin Zhou, Lijuan Huo, Tingwei Wang, Yongjie Zhou, Xiangyang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	PeerJ Inc. 2021
Materias:	Schizophrenia Diabetes mellitus Prevalence China Clinical characteristics Medicine R
Acceso en línea:	https://doaj.org/article/ddab8591423842bdaad1088d447af795
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spelling	oai:doaj.org-article:ddab8591423842bdaad1088d447af7952021-12-02T15:05:16ZThe prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study10.7717/peerj.125532167-8359https://doaj.org/article/ddab8591423842bdaad1088d447af7952021-11-01T00:00:00Zhttps://peerj.com/articles/12553.pdfhttps://peerj.com/articles/12553/https://doaj.org/toc/2167-8359Background Diabetes mellitus (DM) is common among patients with schizophrenia. However, information on patients comorbid DM and schizophrenia is limited in China. The present study investigated the prevalence of DM and its clinical characteristics in Chinese inpatients with chronic schizophrenia. Methods A cross-sectional study was performed in Chinese inpatients with chronic schizophrenia. Diagnosis of Diabetes was established using World Health Organization diagnostic criteria for diabetes mellitus (persistent fasting glucose levels ≥ 126 mg/dl or 2-h plasma glucose ≥ 200 mg/dL after a 75-g Oral Glucose Tolerance Test). Patients were also measured height, weight, waist circumference, hip circumference, triglyceride level, and cholesterol level. Patients’ psychiatric symptoms were measured by the Positive and Negative Syndrome Scale (PANSS). Binary logistic regression analysis was performed to examine the associated demographic and clinical variables in chronic schizophrenia. Results A total of 988 inpatients (64.6% male, average age of 47.19 ± 12.55) was recruited. The prevalence of DM in Chinese patients with chronic schizophrenia was 13.8% (95% CI [11.6–15.9]%). Logistic regression analysis showed that overweight (OR = 1.90, 95% CI [1.20–3.03], p = 0.006), obesity (OR = 1.85, 95% CI [1.07–3.21], p = 0.028), comorbid hypertension (OR = 2.14, 95% CI [1.34–3.42], p = 0.002), and course of schizophrenia (OR = 1.03, 95% CI [1.01–1.06], p = 0.040) were significantly associated with the DM risk in patients with schizophrenia. Conclusion The findings indicated that diabetes mellitus was non-negligible in patients with chronic schizophrenia. Patients with schizophrenia should be regularly monitored for DM. Overweight/obesity, long duration of schizophrenia, and comorbid hypertension possibly were risk factors for diabetes.Yanni WangLingyun ZengLijuan ChenXin ZhouLijuan HuoTingwei WangYongjie ZhouXiangyang ZhangPeerJ Inc.articleSchizophreniaDiabetes mellitusPrevalenceChinaClinical characteristicsMedicineRENPeerJ, Vol 9, p e12553 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia Diabetes mellitus Prevalence China Clinical characteristics Medicine R
spellingShingle	Schizophrenia Diabetes mellitus Prevalence China Clinical characteristics Medicine R Yanni Wang Lingyun Zeng Lijuan Chen Xin Zhou Lijuan Huo Tingwei Wang Yongjie Zhou Xiangyang Zhang The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
description	Background Diabetes mellitus (DM) is common among patients with schizophrenia. However, information on patients comorbid DM and schizophrenia is limited in China. The present study investigated the prevalence of DM and its clinical characteristics in Chinese inpatients with chronic schizophrenia. Methods A cross-sectional study was performed in Chinese inpatients with chronic schizophrenia. Diagnosis of Diabetes was established using World Health Organization diagnostic criteria for diabetes mellitus (persistent fasting glucose levels ≥ 126 mg/dl or 2-h plasma glucose ≥ 200 mg/dL after a 75-g Oral Glucose Tolerance Test). Patients were also measured height, weight, waist circumference, hip circumference, triglyceride level, and cholesterol level. Patients’ psychiatric symptoms were measured by the Positive and Negative Syndrome Scale (PANSS). Binary logistic regression analysis was performed to examine the associated demographic and clinical variables in chronic schizophrenia. Results A total of 988 inpatients (64.6% male, average age of 47.19 ± 12.55) was recruited. The prevalence of DM in Chinese patients with chronic schizophrenia was 13.8% (95% CI [11.6–15.9]%). Logistic regression analysis showed that overweight (OR = 1.90, 95% CI [1.20–3.03], p = 0.006), obesity (OR = 1.85, 95% CI [1.07–3.21], p = 0.028), comorbid hypertension (OR = 2.14, 95% CI [1.34–3.42], p = 0.002), and course of schizophrenia (OR = 1.03, 95% CI [1.01–1.06], p = 0.040) were significantly associated with the DM risk in patients with schizophrenia. Conclusion The findings indicated that diabetes mellitus was non-negligible in patients with chronic schizophrenia. Patients with schizophrenia should be regularly monitored for DM. Overweight/obesity, long duration of schizophrenia, and comorbid hypertension possibly were risk factors for diabetes.
format	article
author	Yanni Wang Lingyun Zeng Lijuan Chen Xin Zhou Lijuan Huo Tingwei Wang Yongjie Zhou Xiangyang Zhang
author_facet	Yanni Wang Lingyun Zeng Lijuan Chen Xin Zhou Lijuan Huo Tingwei Wang Yongjie Zhou Xiangyang Zhang
author_sort	Yanni Wang
title	The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
title_short	The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
title_full	The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
title_fullStr	The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
title_full_unstemmed	The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
title_sort	prevalence and clinical characteristics of diabetes mellitus in chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study
publisher	PeerJ Inc.
publishDate	2021
url	https://doaj.org/article/ddab8591423842bdaad1088d447af795
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The prevalence and clinical characteristics of diabetes mellitus in Chinese inpatients with chronic schizophrenia: a multicenter cross-sectional study

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