Tylectomy Safety in Salvage of Eyes with Retinoblastoma

Intraocular surgery is tabooed in retinoblastoma management, due to the concern of lethal extraocular spread. We reviewed the outcomes of consecutive children with intraocular retinoblastoma diagnosed at 29 Chinese centers between 2012–2014. We compared the outcomes of three categories of treatment:...

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Autores principales:	Junyang Zhao, Qiyan Li, Zhao Xun Feng, Jianping Zhang, Songyi Wu, Liwen Jin, Brenda L. Gallie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinoblastoma tylectomy pars plana vitrectomy surgery resection endoresection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ddaca98c64a8471b9061541506532582
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spelling	oai:doaj.org-article:ddaca98c64a8471b90615415065325822021-11-25T17:04:50ZTylectomy Safety in Salvage of Eyes with Retinoblastoma10.3390/cancers132258622072-6694https://doaj.org/article/ddaca98c64a8471b90615415065325822021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5862https://doaj.org/toc/2072-6694Intraocular surgery is tabooed in retinoblastoma management, due to the concern of lethal extraocular spread. We reviewed the outcomes of consecutive children with intraocular retinoblastoma diagnosed at 29 Chinese centers between 2012–2014. We compared the outcomes of three categories of treatment: eye salvage including tylectomy (Group I), eye salvage without tylectomy (Group II), and primary enucleation (Group III). A total of 960 patients (1243 eyes) were diagnosed: 256 in Group I, 370 in Group II, and 293 in Group III; 41 patients abandoned treatment upfront. The estimated 5-year overall survivals (OS) were, for Group I, 94%, for Group II 89%, and for Group III 95%. The estimated 5-year disease-specific survivals (DSS) were, for Group I, 96%, for Group II 90%, and for Group III 95%. Patients in Group I had a significantly higher 5-year DSS than patients in Group II (<i>p</i> = 0.003) and not significantly different than patients in Group III (<i>p</i> = 0.367). Overall survival was not compromised by the inclusion of tylectomy in eye salvage therapy compared to eye salvage without tylectomy or primary enucleation. Disease-specific survival was better when tylectomy was included in eye salvage treatments. Tylectomy as part of multimodal treatment may contribute to the care of retinoblastoma patients with chemotherapy-resistant tumor, eyes with concomitant ocular complications, or at the risk of treatment abandonment.Junyang ZhaoQiyan LiZhao Xun FengJianping ZhangSongyi WuLiwen JinBrenda L. GallieMDPI AGarticleretinoblastomatylectomypars plana vitrectomysurgeryresectionendoresectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5862, p 5862 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinoblastoma tylectomy pars plana vitrectomy surgery resection endoresection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	retinoblastoma tylectomy pars plana vitrectomy surgery resection endoresection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Junyang Zhao Qiyan Li Zhao Xun Feng Jianping Zhang Songyi Wu Liwen Jin Brenda L. Gallie Tylectomy Safety in Salvage of Eyes with Retinoblastoma
description	Intraocular surgery is tabooed in retinoblastoma management, due to the concern of lethal extraocular spread. We reviewed the outcomes of consecutive children with intraocular retinoblastoma diagnosed at 29 Chinese centers between 2012–2014. We compared the outcomes of three categories of treatment: eye salvage including tylectomy (Group I), eye salvage without tylectomy (Group II), and primary enucleation (Group III). A total of 960 patients (1243 eyes) were diagnosed: 256 in Group I, 370 in Group II, and 293 in Group III; 41 patients abandoned treatment upfront. The estimated 5-year overall survivals (OS) were, for Group I, 94%, for Group II 89%, and for Group III 95%. The estimated 5-year disease-specific survivals (DSS) were, for Group I, 96%, for Group II 90%, and for Group III 95%. Patients in Group I had a significantly higher 5-year DSS than patients in Group II (<i>p</i> = 0.003) and not significantly different than patients in Group III (<i>p</i> = 0.367). Overall survival was not compromised by the inclusion of tylectomy in eye salvage therapy compared to eye salvage without tylectomy or primary enucleation. Disease-specific survival was better when tylectomy was included in eye salvage treatments. Tylectomy as part of multimodal treatment may contribute to the care of retinoblastoma patients with chemotherapy-resistant tumor, eyes with concomitant ocular complications, or at the risk of treatment abandonment.
format	article
author	Junyang Zhao Qiyan Li Zhao Xun Feng Jianping Zhang Songyi Wu Liwen Jin Brenda L. Gallie
author_facet	Junyang Zhao Qiyan Li Zhao Xun Feng Jianping Zhang Songyi Wu Liwen Jin Brenda L. Gallie
author_sort	Junyang Zhao
title	Tylectomy Safety in Salvage of Eyes with Retinoblastoma
title_short	Tylectomy Safety in Salvage of Eyes with Retinoblastoma
title_full	Tylectomy Safety in Salvage of Eyes with Retinoblastoma
title_fullStr	Tylectomy Safety in Salvage of Eyes with Retinoblastoma
title_full_unstemmed	Tylectomy Safety in Salvage of Eyes with Retinoblastoma
title_sort	tylectomy safety in salvage of eyes with retinoblastoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ddaca98c64a8471b9061541506532582
work_keys_str_mv	AT junyangzhao tylectomysafetyinsalvageofeyeswithretinoblastoma AT qiyanli tylectomysafetyinsalvageofeyeswithretinoblastoma AT zhaoxunfeng tylectomysafetyinsalvageofeyeswithretinoblastoma AT jianpingzhang tylectomysafetyinsalvageofeyeswithretinoblastoma AT songyiwu tylectomysafetyinsalvageofeyeswithretinoblastoma AT liwenjin tylectomysafetyinsalvageofeyeswithretinoblastoma AT brendalgallie tylectomysafetyinsalvageofeyeswithretinoblastoma
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Tylectomy Safety in Salvage of Eyes with Retinoblastoma

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