Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G protei...

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Autores principales:	Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc
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spelling	oai:doaj.org-article:ddb2e76a96254f8299931ae5586deefc2021-12-02T14:39:45ZEvidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase10.1038/s41467-018-03522-32041-1723https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03522-3https://doaj.org/toc/2041-1723It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G proteins and AC5.Gemma NavarroArnau CordomíVerónica Casadó-AngueraEstefanía MorenoNing-Sheng CaiAntoni CortésEnric I. CanelaCarmen W. DessauerVicent CasadóLeonardo PardoCarme LluísSergi FerréNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
description	It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G proteins and AC5.
format	article
author	Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré
author_facet	Gemma Navarro Arnau Cordomí Verónica Casadó-Anguera Estefanía Moreno Ning-Sheng Cai Antoni Cortés Enric I. Canela Carmen W. Dessauer Vicent Casadó Leonardo Pardo Carme Lluís Sergi Ferré
author_sort	Gemma Navarro
title	Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
title_short	Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
title_full	Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
title_fullStr	Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
title_full_unstemmed	Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
title_sort	evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc
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Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

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