Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-coupled complexes with their cognate G protei...

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Autores principales: Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc
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