The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity...
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Nature Portfolio
2017
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oai:doaj.org-article:ddb61465d25e4a88871e1ae208a5f36f2021-12-02T17:06:18ZThe activity of TRAF RING homo- and heterodimers is regulated by zinc finger 110.1038/s41467-017-01665-32041-1723https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01665-3https://doaj.org/toc/2041-1723TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity.Adam J. MiddletonRhesa BudhidarmoAnubrita DasJingyi ZhuMartina FoglizzoPeter D. MaceCatherine L. DayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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Science Q Adam J. Middleton Rhesa Budhidarmo Anubrita Das Jingyi Zhu Martina Foglizzo Peter D. Mace Catherine L. Day The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
description |
TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity. |
format |
article |
author |
Adam J. Middleton Rhesa Budhidarmo Anubrita Das Jingyi Zhu Martina Foglizzo Peter D. Mace Catherine L. Day |
author_facet |
Adam J. Middleton Rhesa Budhidarmo Anubrita Das Jingyi Zhu Martina Foglizzo Peter D. Mace Catherine L. Day |
author_sort |
Adam J. Middleton |
title |
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
title_short |
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
title_full |
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
title_fullStr |
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
title_full_unstemmed |
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1 |
title_sort |
activity of traf ring homo- and heterodimers is regulated by zinc finger 1 |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f |
work_keys_str_mv |
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