The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity...

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Autores principales: Adam J. Middleton, Rhesa Budhidarmo, Anubrita Das, Jingyi Zhu, Martina Foglizzo, Peter D. Mace, Catherine L. Day
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f
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spelling oai:doaj.org-article:ddb61465d25e4a88871e1ae208a5f36f2021-12-02T17:06:18ZThe activity of TRAF RING homo- and heterodimers is regulated by zinc finger 110.1038/s41467-017-01665-32041-1723https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01665-3https://doaj.org/toc/2041-1723TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity.Adam J. MiddletonRhesa BudhidarmoAnubrita DasJingyi ZhuMartina FoglizzoPeter D. MaceCatherine L. DayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Adam J. Middleton
Rhesa Budhidarmo
Anubrita Das
Jingyi Zhu
Martina Foglizzo
Peter D. Mace
Catherine L. Day
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
description TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity.
format article
author Adam J. Middleton
Rhesa Budhidarmo
Anubrita Das
Jingyi Zhu
Martina Foglizzo
Peter D. Mace
Catherine L. Day
author_facet Adam J. Middleton
Rhesa Budhidarmo
Anubrita Das
Jingyi Zhu
Martina Foglizzo
Peter D. Mace
Catherine L. Day
author_sort Adam J. Middleton
title The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
title_short The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
title_full The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
title_fullStr The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
title_full_unstemmed The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
title_sort activity of traf ring homo- and heterodimers is regulated by zinc finger 1
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f
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