The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

TRAF6 is a RING E3 ligase that builds Lys63-linked ubiquitin chains. Here, the authors present the crystal structure of TRAF6 bound to the Ubc13~Ub conjugate, which, together with biochemical assays, reveals the role of the zinc finger domains and why RING dimerisation is required for TRAF6 activity...

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Autores principales: Adam J. Middleton, Rhesa Budhidarmo, Anubrita Das, Jingyi Zhu, Martina Foglizzo, Peter D. Mace, Catherine L. Day
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/ddb61465d25e4a88871e1ae208a5f36f
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