Detection and mapping of DNA methylation with 2D material nanopores

Epigenetics: DNA methylation electronically detected by 2D nanopores As one the most common epigenetic modifications in eukaryotic genomes, DNA methylation plays a crucial role in the expression of genes in mammalian cells. It holds great promise as a biomarker to investigate cell development and ag...

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Autores principales:	Hu Qiu, Aditya Sarathy, Klaus Schulten, Jean-Pierre Leburton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Materials of engineering and construction. Mechanics of materials TA401-492 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ddb732df7adc41edbedb4a5bc7f75434
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spelling	oai:doaj.org-article:ddb732df7adc41edbedb4a5bc7f754342021-12-02T13:41:45ZDetection and mapping of DNA methylation with 2D material nanopores10.1038/s41699-017-0005-72397-7132https://doaj.org/article/ddb732df7adc41edbedb4a5bc7f754342017-04-01T00:00:00Zhttps://doi.org/10.1038/s41699-017-0005-7https://doaj.org/toc/2397-7132Epigenetics: DNA methylation electronically detected by 2D nanopores As one the most common epigenetic modifications in eukaryotic genomes, DNA methylation plays a crucial role in the expression of genes in mammalian cells. It holds great promise as a biomarker to investigate cell development and aging, and to be used in risk assessment and early diagnosis of diseases such as cancer. A team lead by Jean–Pierre Leburton at the University of Illinois in the USA shows by numerical simulation that the use of a few angstrom wide nanopores in a tri-atomic membrane of semiconducting molybdenum di-sulfide (MoS2) offers a powerful way to detect and map electronically and with high resolution the presence of individual methyl groups on a DNA molecule, thereby paving the way towards fast and low-cost DNA sequencing techniques for personal medicine.Hu QiuAditya SarathyKlaus SchultenJean-Pierre LeburtonNature PortfolioarticleMaterials of engineering and construction. Mechanics of materialsTA401-492ChemistryQD1-999ENnpj 2D Materials and Applications, Vol 1, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials of engineering and construction. Mechanics of materials TA401-492 Chemistry QD1-999
spellingShingle	Materials of engineering and construction. Mechanics of materials TA401-492 Chemistry QD1-999 Hu Qiu Aditya Sarathy Klaus Schulten Jean-Pierre Leburton Detection and mapping of DNA methylation with 2D material nanopores
description	Epigenetics: DNA methylation electronically detected by 2D nanopores As one the most common epigenetic modifications in eukaryotic genomes, DNA methylation plays a crucial role in the expression of genes in mammalian cells. It holds great promise as a biomarker to investigate cell development and aging, and to be used in risk assessment and early diagnosis of diseases such as cancer. A team lead by Jean–Pierre Leburton at the University of Illinois in the USA shows by numerical simulation that the use of a few angstrom wide nanopores in a tri-atomic membrane of semiconducting molybdenum di-sulfide (MoS2) offers a powerful way to detect and map electronically and with high resolution the presence of individual methyl groups on a DNA molecule, thereby paving the way towards fast and low-cost DNA sequencing techniques for personal medicine.
format	article
author	Hu Qiu Aditya Sarathy Klaus Schulten Jean-Pierre Leburton
author_facet	Hu Qiu Aditya Sarathy Klaus Schulten Jean-Pierre Leburton
author_sort	Hu Qiu
title	Detection and mapping of DNA methylation with 2D material nanopores
title_short	Detection and mapping of DNA methylation with 2D material nanopores
title_full	Detection and mapping of DNA methylation with 2D material nanopores
title_fullStr	Detection and mapping of DNA methylation with 2D material nanopores
title_full_unstemmed	Detection and mapping of DNA methylation with 2D material nanopores
title_sort	detection and mapping of dna methylation with 2d material nanopores
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ddb732df7adc41edbedb4a5bc7f75434
work_keys_str_mv	AT huqiu detectionandmappingofdnamethylationwith2dmaterialnanopores AT adityasarathy detectionandmappingofdnamethylationwith2dmaterialnanopores AT klausschulten detectionandmappingofdnamethylationwith2dmaterialnanopores AT jeanpierreleburton detectionandmappingofdnamethylationwith2dmaterialnanopores
_version_	1718392585608757248

Detection and mapping of DNA methylation with 2D material nanopores

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