Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors

Microbial evolution often involves transient phenotypes and sequential development of multiple mutations of unclear relevance. Here, the authors show that the evolution of non-growing E. coli cells can be driven by alterations in pyrimidine nucleoside levels associated with colony ageing and/or due...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ida Lauritsen, Pernille Ott Frendorf, Silvia Capucci, Sophia A. H. Heyde, Sarah D. Blomquist, Sofie Wendel, Emil C. Fischer, Agnieszka Sekowska, Antoine Danchin, Morten H. H. Nørholm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddb79980ec96494cbf407a7e2b45ecb8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ddb79980ec96494cbf407a7e2b45ecb8
record_format	dspace
spelling	oai:doaj.org-article:ddb79980ec96494cbf407a7e2b45ecb82021-12-02T16:56:48ZTemporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors10.1038/s41467-021-26098-x2041-1723https://doaj.org/article/ddb79980ec96494cbf407a7e2b45ecb82021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26098-xhttps://doaj.org/toc/2041-1723Microbial evolution often involves transient phenotypes and sequential development of multiple mutations of unclear relevance. Here, the authors show that the evolution of non-growing E. coli cells can be driven by alterations in pyrimidine nucleoside levels associated with colony ageing and/or due to mutations in metabolic or regulatory genes.Ida LauritsenPernille Ott FrendorfSilvia CapucciSophia A. H. HeydeSarah D. BlomquistSofie WendelEmil C. FischerAgnieszka SekowskaAntoine DanchinMorten H. H. NørholmNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ida Lauritsen Pernille Ott Frendorf Silvia Capucci Sophia A. H. Heyde Sarah D. Blomquist Sofie Wendel Emil C. Fischer Agnieszka Sekowska Antoine Danchin Morten H. H. Nørholm Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
description	Microbial evolution often involves transient phenotypes and sequential development of multiple mutations of unclear relevance. Here, the authors show that the evolution of non-growing E. coli cells can be driven by alterations in pyrimidine nucleoside levels associated with colony ageing and/or due to mutations in metabolic or regulatory genes.
format	article
author	Ida Lauritsen Pernille Ott Frendorf Silvia Capucci Sophia A. H. Heyde Sarah D. Blomquist Sofie Wendel Emil C. Fischer Agnieszka Sekowska Antoine Danchin Morten H. H. Nørholm
author_facet	Ida Lauritsen Pernille Ott Frendorf Silvia Capucci Sophia A. H. Heyde Sarah D. Blomquist Sofie Wendel Emil C. Fischer Agnieszka Sekowska Antoine Danchin Morten H. H. Nørholm
author_sort	Ida Lauritsen
title	Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
title_short	Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
title_full	Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
title_fullStr	Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
title_full_unstemmed	Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors
title_sort	temporal evolution of master regulator crp identifies pyrimidines as catabolite modulator factors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddb79980ec96494cbf407a7e2b45ecb8
work_keys_str_mv	AT idalauritsen temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT pernilleottfrendorf temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT silviacapucci temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT sophiaahheyde temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT sarahdblomquist temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT sofiewendel temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT emilcfischer temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT agnieszkasekowska temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT antoinedanchin temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors AT mortenhhnørholm temporalevolutionofmasterregulatorcrpidentifiespyrimidinesascatabolitemodulatorfactors
_version_	1718382710235332608

Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors

Ejemplares similares