High-resolution characterization of gene function using single-cell CRISPR tiling screen

Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ddb7b59f991343969e3fce23606cbf5c
record_format	dspace
spelling	oai:doaj.org-article:ddb7b59f991343969e3fce23606cbf5c2021-12-02T14:34:12ZHigh-resolution characterization of gene function using single-cell CRISPR tiling screen10.1038/s41467-021-24324-02041-1723https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24324-0https://doaj.org/toc/2041-1723Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.Lu YangAnthony K. N. ChanKazuya MiyashitaChristopher D. DelaneyXi WangHongzhi LiSheela Pangeni PokharelSandra LiMingli LiXiaobao XuWei LuQiao LiuNicole MattsonKevin Yining ChenJinhui WangYate-Ching YuanDavid HorneSteven T. RosenYadira Soto-FelicianoZhaohui FengTakayuki HoshiiGang XiaoMarkus MüschenJianjun ChenScott A. ArmstrongChun-Wei ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Yang Anthony K. N. Chan Kazuya Miyashita Christopher D. Delaney Xi Wang Hongzhi Li Sheela Pangeni Pokharel Sandra Li Mingli Li Xiaobao Xu Wei Lu Qiao Liu Nicole Mattson Kevin Yining Chen Jinhui Wang Yate-Ching Yuan David Horne Steven T. Rosen Yadira Soto-Feliciano Zhaohui Feng Takayuki Hoshii Gang Xiao Markus Müschen Jianjun Chen Scott A. Armstrong Chun-Wei Chen High-resolution characterization of gene function using single-cell CRISPR tiling screen
description	Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
format	article
author	Lu Yang Anthony K. N. Chan Kazuya Miyashita Christopher D. Delaney Xi Wang Hongzhi Li Sheela Pangeni Pokharel Sandra Li Mingli Li Xiaobao Xu Wei Lu Qiao Liu Nicole Mattson Kevin Yining Chen Jinhui Wang Yate-Ching Yuan David Horne Steven T. Rosen Yadira Soto-Feliciano Zhaohui Feng Takayuki Hoshii Gang Xiao Markus Müschen Jianjun Chen Scott A. Armstrong Chun-Wei Chen
author_facet	Lu Yang Anthony K. N. Chan Kazuya Miyashita Christopher D. Delaney Xi Wang Hongzhi Li Sheela Pangeni Pokharel Sandra Li Mingli Li Xiaobao Xu Wei Lu Qiao Liu Nicole Mattson Kevin Yining Chen Jinhui Wang Yate-Ching Yuan David Horne Steven T. Rosen Yadira Soto-Feliciano Zhaohui Feng Takayuki Hoshii Gang Xiao Markus Müschen Jianjun Chen Scott A. Armstrong Chun-Wei Chen
author_sort	Lu Yang
title	High-resolution characterization of gene function using single-cell CRISPR tiling screen
title_short	High-resolution characterization of gene function using single-cell CRISPR tiling screen
title_full	High-resolution characterization of gene function using single-cell CRISPR tiling screen
title_fullStr	High-resolution characterization of gene function using single-cell CRISPR tiling screen
title_full_unstemmed	High-resolution characterization of gene function using single-cell CRISPR tiling screen
title_sort	high-resolution characterization of gene function using single-cell crispr tiling screen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
work_keys_str_mv	AT luyang highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT anthonyknchan highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT kazuyamiyashita highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT christopherddelaney highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT xiwang highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT hongzhili highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT sheelapangenipokharel highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT sandrali highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT minglili highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT xiaobaoxu highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT weilu highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT qiaoliu highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT nicolemattson highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT kevinyiningchen highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT jinhuiwang highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT yatechingyuan highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT davidhorne highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT steventrosen highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT yadirasotofeliciano highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT zhaohuifeng highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT takayukihoshii highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT gangxiao highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT markusmuschen highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT jianjunchen highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT scottaarmstrong highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen AT chunweichen highresolutioncharacterizationofgenefunctionusingsinglecellcrisprtilingscreen
_version_	1718391163030863872

High-resolution characterization of gene function using single-cell CRISPR tiling screen

Ejemplares similares