Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

Abstract Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated...

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Autores principales:	Noah T. Ventimiglia, Emily M. Stucke, Drissa Coulibaly, Andrea A. Berry, Kirsten E. Lyke, Matthew B. Laurens, Jason A. Bailey, Matthew Adams, Amadou Niangaly, Abdoulaye K. Kone, Shannon Takala-Harrison, Bourema Kouriba, Ogobara K. Doumbo, Phillip L. Felgner, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ddb8e7ed5a5b4e8b9edbd511c784d497
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spelling	oai:doaj.org-article:ddb8e7ed5a5b4e8b9edbd511c784d4972021-12-02T18:30:57ZMalian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation10.1038/s41598-021-92974-72045-2322https://doaj.org/article/ddb8e7ed5a5b4e8b9edbd511c784d4972021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92974-7https://doaj.org/toc/2045-2322Abstract Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated with protection against severe disease. We hypothesized that given lifelong P. falciparum exposure, Malian adults would have broad PfEMP1 serorecognition and high seroreactivity levels during follow-up, particularly to non-CD36-binding PfEMP1s such as those that attach to endothelial protein C receptor (EPCR) and intercellular adhesion molecule-1 (ICAM-1). Using a protein microarray, we determined serologic responses to 166 reference PfEMP1 fragments during a dry and subsequent malaria transmission season in Malian adults. Malian adult sera had PfEMP1 serologic responses throughout the year, with decreased reactivity to a small subset of PfEMP1 fragments during the dry season and increases in reactivity to a different subset of PfEMP1 fragments during the subsequent peak malaria transmission season, especially for intracellular PfEMP1 domains. For some individuals, PfEMP1 serologic responses increased after the dry season, suggesting antigenic switching during asymptomatic infection. Adults were more likely to experience variable serorecognition of CD36-binding PfEMP1s than non-CD36-binding PfEMP1s that bind EPCR or ICAM-1, which remained serorecognized throughout the year. Sustained seroreactivity to non-CD36-binding PfEMP1s throughout adulthood amid seasonal fluctuation patterns may reflect underlying protective severe malaria immunity and merits further investigation.Noah T. VentimigliaEmily M. StuckeDrissa CoulibalyAndrea A. BerryKirsten E. LykeMatthew B. LaurensJason A. BaileyMatthew AdamsAmadou NiangalyAbdoulaye K. KoneShannon Takala-HarrisonBourema KouribaOgobara K. DoumboPhillip L. FelgnerChristopher V. PloweMahamadou A. TheraMark A. TravassosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noah T. Ventimiglia Emily M. Stucke Drissa Coulibaly Andrea A. Berry Kirsten E. Lyke Matthew B. Laurens Jason A. Bailey Matthew Adams Amadou Niangaly Abdoulaye K. Kone Shannon Takala-Harrison Bourema Kouriba Ogobara K. Doumbo Phillip L. Felgner Christopher V. Plowe Mahamadou A. Thera Mark A. Travassos Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
description	Abstract Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-CD36-binding PfEMP1s are associated with protection against severe disease. We hypothesized that given lifelong P. falciparum exposure, Malian adults would have broad PfEMP1 serorecognition and high seroreactivity levels during follow-up, particularly to non-CD36-binding PfEMP1s such as those that attach to endothelial protein C receptor (EPCR) and intercellular adhesion molecule-1 (ICAM-1). Using a protein microarray, we determined serologic responses to 166 reference PfEMP1 fragments during a dry and subsequent malaria transmission season in Malian adults. Malian adult sera had PfEMP1 serologic responses throughout the year, with decreased reactivity to a small subset of PfEMP1 fragments during the dry season and increases in reactivity to a different subset of PfEMP1 fragments during the subsequent peak malaria transmission season, especially for intracellular PfEMP1 domains. For some individuals, PfEMP1 serologic responses increased after the dry season, suggesting antigenic switching during asymptomatic infection. Adults were more likely to experience variable serorecognition of CD36-binding PfEMP1s than non-CD36-binding PfEMP1s that bind EPCR or ICAM-1, which remained serorecognized throughout the year. Sustained seroreactivity to non-CD36-binding PfEMP1s throughout adulthood amid seasonal fluctuation patterns may reflect underlying protective severe malaria immunity and merits further investigation.
format	article
author	Noah T. Ventimiglia Emily M. Stucke Drissa Coulibaly Andrea A. Berry Kirsten E. Lyke Matthew B. Laurens Jason A. Bailey Matthew Adams Amadou Niangaly Abdoulaye K. Kone Shannon Takala-Harrison Bourema Kouriba Ogobara K. Doumbo Phillip L. Felgner Christopher V. Plowe Mahamadou A. Thera Mark A. Travassos
author_facet	Noah T. Ventimiglia Emily M. Stucke Drissa Coulibaly Andrea A. Berry Kirsten E. Lyke Matthew B. Laurens Jason A. Bailey Matthew Adams Amadou Niangaly Abdoulaye K. Kone Shannon Takala-Harrison Bourema Kouriba Ogobara K. Doumbo Phillip L. Felgner Christopher V. Plowe Mahamadou A. Thera Mark A. Travassos
author_sort	Noah T. Ventimiglia
title	Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
title_short	Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
title_full	Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
title_fullStr	Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
title_full_unstemmed	Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation
title_sort	malian adults maintain serologic responses to virulent pfemp1s amid seasonal patterns of fluctuation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddb8e7ed5a5b4e8b9edbd511c784d497
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Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

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