Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery

Xin Mu,1,2 Shenglong Gan,1,2 Yao Wang,1,2 Hao Li,1,2 Guofu Zhou1,21Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China No...

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Autores principales:	Mu X, Gan S, Wang Y, Li H, Zhou G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	vesicle amphiphilic block copolymer stimulus-responsive self-assembled drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ddb99e0d6c234f87afd9ab58b47e70a8
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spelling	oai:doaj.org-article:ddb99e0d6c234f87afd9ab58b47e70a82021-12-02T05:43:58ZStimulus-responsive vesicular polymer nano-integrators for drug and gene delivery1178-2013https://doaj.org/article/ddb99e0d6c234f87afd9ab58b47e70a82019-07-01T00:00:00Zhttps://www.dovepress.com/stimulus-responsive-vesicular-polymer-nano-integrators-for-drug-and-ge-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xin Mu,1,2 Shenglong Gan,1,2 Yao Wang,1,2 Hao Li,1,2 Guofu Zhou1,21Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of China; 2National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of ChinaAbstract: Over the past two decades, nano-sized biosystems have increasingly been utilized to deliver various pharmaceutical agents to a specific region, organ or tissue for controllable precision therapy. Whether solid nanohydrogel, nanosphere, nanoparticle, nanosheet, micelles and lipoproteins, or “hollow” nanobubble, liposome, nanocapsule, and nanovesicle, all of them can exhibit outstanding loading and releasing capability as a drug vehicle – in particular polymeric nanovesicle, a microscopic hollow sphere that encloses a water core with a thin polymer membrane. Besides excellent stability, toughness and liposome-like compatibility, polymeric nanovesicles offer considerable scope for tailoring properties by changing their chemical structure, block lengths, stimulus-responsiveness and even conjugation with biomolecules. In this review, we summarize the latest advances in stimulus-responsive polymeric nanovesicles for biomedical applications. Different functionalized polymers are in development to construct more complex multiple responsive nanovesicles in delivery systems, medical imaging, biosensors and so on.Keywords: nanovesicle, stimulus-responsive, amphiphilic block copolymer, self-assembled, drug deliveryMu XGan SWang YLi HZhou GDove Medical Pressarticlevesicleamphiphilic block copolymerstimulus-responsiveself-assembleddrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5415-5434 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vesicle amphiphilic block copolymer stimulus-responsive self-assembled drug delivery Medicine (General) R5-920
spellingShingle	vesicle amphiphilic block copolymer stimulus-responsive self-assembled drug delivery Medicine (General) R5-920 Mu X Gan S Wang Y Li H Zhou G Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
description	Xin Mu,1,2 Shenglong Gan,1,2 Yao Wang,1,2 Hao Li,1,2 Guofu Zhou1,21Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of China; 2National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, People’s Republic of ChinaAbstract: Over the past two decades, nano-sized biosystems have increasingly been utilized to deliver various pharmaceutical agents to a specific region, organ or tissue for controllable precision therapy. Whether solid nanohydrogel, nanosphere, nanoparticle, nanosheet, micelles and lipoproteins, or “hollow” nanobubble, liposome, nanocapsule, and nanovesicle, all of them can exhibit outstanding loading and releasing capability as a drug vehicle – in particular polymeric nanovesicle, a microscopic hollow sphere that encloses a water core with a thin polymer membrane. Besides excellent stability, toughness and liposome-like compatibility, polymeric nanovesicles offer considerable scope for tailoring properties by changing their chemical structure, block lengths, stimulus-responsiveness and even conjugation with biomolecules. In this review, we summarize the latest advances in stimulus-responsive polymeric nanovesicles for biomedical applications. Different functionalized polymers are in development to construct more complex multiple responsive nanovesicles in delivery systems, medical imaging, biosensors and so on.Keywords: nanovesicle, stimulus-responsive, amphiphilic block copolymer, self-assembled, drug delivery
format	article
author	Mu X Gan S Wang Y Li H Zhou G
author_facet	Mu X Gan S Wang Y Li H Zhou G
author_sort	Mu X
title	Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
title_short	Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
title_full	Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
title_fullStr	Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
title_full_unstemmed	Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
title_sort	stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ddb99e0d6c234f87afd9ab58b47e70a8
work_keys_str_mv	AT mux stimulusresponsivevesicularpolymernanointegratorsfordrugandgenedelivery AT gans stimulusresponsivevesicularpolymernanointegratorsfordrugandgenedelivery AT wangy stimulusresponsivevesicularpolymernanointegratorsfordrugandgenedelivery AT lih stimulusresponsivevesicularpolymernanointegratorsfordrugandgenedelivery AT zhoug stimulusresponsivevesicularpolymernanointegratorsfordrugandgenedelivery
_version_	1718400262813515776

Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery

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