Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators

Abstract Multi-tracer imaging can provide useful information in the definitive diagnosis and research of medical, biological, and pharmaceutical sciences. Single-photon emission computed tomography (SPECT) is one of the nuclear medicine imaging modalities widely used for diagnosis or medical researc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mizuki Uenomachi, Kenji Shimazoe, Kenichiro Ogane, Hiroyuki Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ddbd58de1f8f466593a43c2aa1bf7aa2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ddbd58de1f8f466593a43c2aa1bf7aa2
record_format	dspace
spelling	oai:doaj.org-article:ddbd58de1f8f466593a43c2aa1bf7aa22021-12-02T18:02:49ZSimultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators10.1038/s41598-021-92583-42045-2322https://doaj.org/article/ddbd58de1f8f466593a43c2aa1bf7aa22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92583-4https://doaj.org/toc/2045-2322Abstract Multi-tracer imaging can provide useful information in the definitive diagnosis and research of medical, biological, and pharmaceutical sciences. Single-photon emission computed tomography (SPECT) is one of the nuclear medicine imaging modalities widely used for diagnosis or medical research and has a multi-tracer imaging capability. One of the drawbacks of multi-tracer imaging is crosstalk from other gamma rays, which affects the reconstructed image. Scattering correction methods, such as the dual- and triple-energy window methods, are used for conventional SPECT imaging to reduce the background caused by the crosstalk. This study proposes another crosstalk reduction method. Some nuclides emit two or more gamma rays through intermediate levels. Thus, detecting these gamma rays with the coincidence method allows us to distinguish a true gamma ray signal and a background signal. The nuclide position can be estimated at the intersection of two gamma rays using collimators. We demonstrate herein simultaneous 111In and 177Lu imaging via the double-photon coincidence method using GAGG detectors and parallel hole collimators. The double-photon coincidence method greatly reduces the background caused by other gamma rays and offers higher-quality images than does conventional imaging.Mizuki UenomachiKenji ShimazoeKenichiro OganeHiroyuki TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mizuki Uenomachi Kenji Shimazoe Kenichiro Ogane Hiroyuki Takahashi Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
description	Abstract Multi-tracer imaging can provide useful information in the definitive diagnosis and research of medical, biological, and pharmaceutical sciences. Single-photon emission computed tomography (SPECT) is one of the nuclear medicine imaging modalities widely used for diagnosis or medical research and has a multi-tracer imaging capability. One of the drawbacks of multi-tracer imaging is crosstalk from other gamma rays, which affects the reconstructed image. Scattering correction methods, such as the dual- and triple-energy window methods, are used for conventional SPECT imaging to reduce the background caused by the crosstalk. This study proposes another crosstalk reduction method. Some nuclides emit two or more gamma rays through intermediate levels. Thus, detecting these gamma rays with the coincidence method allows us to distinguish a true gamma ray signal and a background signal. The nuclide position can be estimated at the intersection of two gamma rays using collimators. We demonstrate herein simultaneous 111In and 177Lu imaging via the double-photon coincidence method using GAGG detectors and parallel hole collimators. The double-photon coincidence method greatly reduces the background caused by other gamma rays and offers higher-quality images than does conventional imaging.
format	article
author	Mizuki Uenomachi Kenji Shimazoe Kenichiro Ogane Hiroyuki Takahashi
author_facet	Mizuki Uenomachi Kenji Shimazoe Kenichiro Ogane Hiroyuki Takahashi
author_sort	Mizuki Uenomachi
title	Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
title_short	Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
title_full	Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
title_fullStr	Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
title_full_unstemmed	Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
title_sort	simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddbd58de1f8f466593a43c2aa1bf7aa2
work_keys_str_mv	AT mizukiuenomachi simultaneousmultinuclideimagingviadoublephotoncoincidencemethodwithparallelholecollimators AT kenjishimazoe simultaneousmultinuclideimagingviadoublephotoncoincidencemethodwithparallelholecollimators AT kenichiroogane simultaneousmultinuclideimagingviadoublephotoncoincidencemethodwithparallelholecollimators AT hiroyukitakahashi simultaneousmultinuclideimagingviadoublephotoncoincidencemethodwithparallelholecollimators
_version_	1718378898707709952

Simultaneous multi-nuclide imaging via double-photon coincidence method with parallel hole collimators

Ejemplares similares