Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome

Yeongseon Ahn,1 Hyejin Lee,2 Yoon Shin Cho1 1Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, Republic of Korea; 2Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of KoreaCorrespondence: Yoon Shin ChoDepartment of Biomedical Scien...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ahn Y, Lee H, Cho YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	female obesity polycystic ovarian syndrome causal relation genome-wide association study mendelian randomization Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ddbdfbaeff9a4624bbeec1f84e0df6c4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ddbdfbaeff9a4624bbeec1f84e0df6c4
record_format	dspace
spelling	oai:doaj.org-article:ddbdfbaeff9a4624bbeec1f84e0df6c42021-12-02T11:10:14ZIdentification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome1178-7007https://doaj.org/article/ddbdfbaeff9a4624bbeec1f84e0df6c42020-11-01T00:00:00Zhttps://www.dovepress.com/identification-of-genetic-variants-for-female-obesity-and-evaluation-o-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yeongseon Ahn,1 Hyejin Lee,2 Yoon Shin Cho1 1Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, Republic of Korea; 2Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of KoreaCorrespondence: Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, Gangwon-do 24252, Republic of KoreaTel +82-33-248-2111Fax +82-33-256-3420Email yooncho33@hallym.ac.krPurpose: Observational studies have demonstrated an increased risk of polycystic ovarian syndrome (PCOS) in obese women. This study aimed to identify genetic variants influencing obesity in females and to evaluate the causal association between genetically defined obesity and PCOS in Korean women.Methods: Two-stage GWAS was conducted to identify genetic variants influencing obesity traits (such as body mass index [BMI], waist–hip ratio [WHR], and waist circumference [WC]) in Korean women. Two-sample Mendelian randomization (MR) analysis was employed to evaluate the causal effect of variants as genetic instruments for female obesity on PCOS.Results: Meta-analysis of 9953 females combining discovery (N = 4658) and replication (N = 5295) stages detected four (rs11162584, rs6760543, rs828104, rs56137030), six (rs139702234, rs2341967, rs73059848, rs5020945, rs550532151, rs61971548), and two genetic variants (rs7722169, rs7206790) suggesting a highly significant association (P < 1× 10− 6) with BMI, WHR, and WC, respectively. Of these, an intron variant rs56137030 in FTO achieved genome-wide significant association (P = 3.39× 10− 8) with BMI in females. Using variants for female obesity, their effect on PCOS in 946 cases and 976 controls was evaluated by MR analysis. MR results indicated no significant association between genetically defined obesity and PCOS in Korean women.Conclusion: This study, for the first time, revealed genetic variants for female obesity in the Korean population and reported no causal association between genetically defined obesity and PCOS in Korean women.Keywords: female obesity, polycystic ovarian syndrome, causal relation, genome-wide association study, Mendelian randomizationAhn YLee HCho YSDove Medical Pressarticlefemale obesitypolycystic ovarian syndromecausal relationgenome-wide association studymendelian randomizationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4311-4322 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	female obesity polycystic ovarian syndrome causal relation genome-wide association study mendelian randomization Specialties of internal medicine RC581-951
spellingShingle	female obesity polycystic ovarian syndrome causal relation genome-wide association study mendelian randomization Specialties of internal medicine RC581-951 Ahn Y Lee H Cho YS Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
description	Yeongseon Ahn,1 Hyejin Lee,2 Yoon Shin Cho1 1Department of Biomedical Science, Hallym University, Chuncheon, Gangwon-do, Republic of Korea; 2Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of KoreaCorrespondence: Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, Gangwon-do 24252, Republic of KoreaTel +82-33-248-2111Fax +82-33-256-3420Email yooncho33@hallym.ac.krPurpose: Observational studies have demonstrated an increased risk of polycystic ovarian syndrome (PCOS) in obese women. This study aimed to identify genetic variants influencing obesity in females and to evaluate the causal association between genetically defined obesity and PCOS in Korean women.Methods: Two-stage GWAS was conducted to identify genetic variants influencing obesity traits (such as body mass index [BMI], waist–hip ratio [WHR], and waist circumference [WC]) in Korean women. Two-sample Mendelian randomization (MR) analysis was employed to evaluate the causal effect of variants as genetic instruments for female obesity on PCOS.Results: Meta-analysis of 9953 females combining discovery (N = 4658) and replication (N = 5295) stages detected four (rs11162584, rs6760543, rs828104, rs56137030), six (rs139702234, rs2341967, rs73059848, rs5020945, rs550532151, rs61971548), and two genetic variants (rs7722169, rs7206790) suggesting a highly significant association (P < 1× 10− 6) with BMI, WHR, and WC, respectively. Of these, an intron variant rs56137030 in FTO achieved genome-wide significant association (P = 3.39× 10− 8) with BMI in females. Using variants for female obesity, their effect on PCOS in 946 cases and 976 controls was evaluated by MR analysis. MR results indicated no significant association between genetically defined obesity and PCOS in Korean women.Conclusion: This study, for the first time, revealed genetic variants for female obesity in the Korean population and reported no causal association between genetically defined obesity and PCOS in Korean women.Keywords: female obesity, polycystic ovarian syndrome, causal relation, genome-wide association study, Mendelian randomization
format	article
author	Ahn Y Lee H Cho YS
author_facet	Ahn Y Lee H Cho YS
author_sort	Ahn Y
title	Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
title_short	Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
title_full	Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
title_fullStr	Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
title_full_unstemmed	Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome
title_sort	identification of genetic variants for female obesity and evaluation of the causal role of genetically defined obesity in polycystic ovarian syndrome
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ddbdfbaeff9a4624bbeec1f84e0df6c4
work_keys_str_mv	AT ahny identificationofgeneticvariantsforfemaleobesityandevaluationofthecausalroleofgeneticallydefinedobesityinpolycysticovariansyndrome AT leeh identificationofgeneticvariantsforfemaleobesityandevaluationofthecausalroleofgeneticallydefinedobesityinpolycysticovariansyndrome AT choys identificationofgeneticvariantsforfemaleobesityandevaluationofthecausalroleofgeneticallydefinedobesityinpolycysticovariansyndrome
_version_	1718396199394869248

Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome

Ejemplares similares