A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section

BACKGROUND AND OBJECTIVE: More than 30% of deliveries are carried out by cesarean section. Spinal anesthesia is the routine and safe method but, in some situations, general anesthesia is selected instead. One complication in general anesthesia for cesarean is intraoperative awareness which sometimes...

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Autores principales:	SM Rabiee, E Alijanpour, F Naziri, H Alreza, V Esmaeili
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	cesarean section depth of anesthesia hemodynamic variables sodium thiopental propofol Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ddc2b2580dc44f2db63becba06bfb9aa
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spelling	oai:doaj.org-article:ddc2b2580dc44f2db63becba06bfb9aa2021-11-10T08:53:26ZA Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section1561-41072251-7170https://doaj.org/article/ddc2b2580dc44f2db63becba06bfb9aa2012-09-01T00:00:00Zhttp://jbums.org/article-1-4186-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: More than 30% of deliveries are carried out by cesarean section. Spinal anesthesia is the routine and safe method but, in some situations, general anesthesia is selected instead. One complication in general anesthesia for cesarean is intraoperative awareness which sometimes can lead to disabling psychological sequela. This study is designed to compare sodium thiopental and propofol as induction agents in depth of anesthesia and hemodynamic variations in mothers and APGAR score of neonates. METHODS: This double blind clinical trial was conducted on 50 full term parturients undergoing elective cesarean section. They were randomly assigned into sodium thiopental (n=25) and propofol (n=25) groups. All patients received intravenous midazolam 1.5mg and lidocaine 1mg/kg. General anesthesia was induced for the first group by sodium thiopental (5mg/kg) and the second group by propofol (2.5mg/kg) and all patients then received succinylcholine (1.5mg/kg) as muscle relaxant for facilitation of laryngoscopy and tracheal intubation. Anesthesia was maintained with 50% O2 -50% N2O and 0.6% Isoflurane. Maternal BIS values (Bispecral Index System) and hemodynamic variables and also APGAR score of neonates were evaluated and recorded. FINDINGS: BIS values in different times, was similar and less than 60 (p=0.637). Maternal mean arterial pressure (p=0.630) and heart rate (p=0.623) and neonatal APGAR score in first minute (p=0.105) and fifth minute (p=0.185) were not significantly different.CONCLUSION: The effect of sodium thiopental and propofol on depth of anesthesia and hemodynamic variables of mothers as well as neonatal APGAR scores was similar and propofol can be used as an appropriate alternative for sodium thiopental in induction of anesthesia for cesarean section.SM Rabiee,E AlijanpourF NaziriH AlrezaV EsmaeiliBabol University of Medical Sciencesarticlecesarean sectiondepth of anesthesiahemodynamic variablessodium thiopentalpropofolMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 7-12 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	cesarean section depth of anesthesia hemodynamic variables sodium thiopental propofol Medicine R Medicine (General) R5-920
spellingShingle	cesarean section depth of anesthesia hemodynamic variables sodium thiopental propofol Medicine R Medicine (General) R5-920 SM Rabiee, E Alijanpour F Naziri H Alreza V Esmaeili A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
description	BACKGROUND AND OBJECTIVE: More than 30% of deliveries are carried out by cesarean section. Spinal anesthesia is the routine and safe method but, in some situations, general anesthesia is selected instead. One complication in general anesthesia for cesarean is intraoperative awareness which sometimes can lead to disabling psychological sequela. This study is designed to compare sodium thiopental and propofol as induction agents in depth of anesthesia and hemodynamic variations in mothers and APGAR score of neonates. METHODS: This double blind clinical trial was conducted on 50 full term parturients undergoing elective cesarean section. They were randomly assigned into sodium thiopental (n=25) and propofol (n=25) groups. All patients received intravenous midazolam 1.5mg and lidocaine 1mg/kg. General anesthesia was induced for the first group by sodium thiopental (5mg/kg) and the second group by propofol (2.5mg/kg) and all patients then received succinylcholine (1.5mg/kg) as muscle relaxant for facilitation of laryngoscopy and tracheal intubation. Anesthesia was maintained with 50% O2 -50% N2O and 0.6% Isoflurane. Maternal BIS values (Bispecral Index System) and hemodynamic variables and also APGAR score of neonates were evaluated and recorded. FINDINGS: BIS values in different times, was similar and less than 60 (p=0.637). Maternal mean arterial pressure (p=0.630) and heart rate (p=0.623) and neonatal APGAR score in first minute (p=0.105) and fifth minute (p=0.185) were not significantly different.CONCLUSION: The effect of sodium thiopental and propofol on depth of anesthesia and hemodynamic variables of mothers as well as neonatal APGAR scores was similar and propofol can be used as an appropriate alternative for sodium thiopental in induction of anesthesia for cesarean section.
format	article
author	SM Rabiee, E Alijanpour F Naziri H Alreza V Esmaeili
author_facet	SM Rabiee, E Alijanpour F Naziri H Alreza V Esmaeili
author_sort	SM Rabiee,
title	A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
title_short	A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
title_full	A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
title_fullStr	A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
title_full_unstemmed	A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section
title_sort	comparison of depth of anesthesia and hemodynamic variables with sodium thiopental and propofol as induction agents for cesarean section
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/ddc2b2580dc44f2db63becba06bfb9aa
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A Comparison of Depth of Anesthesia and Hemodynamic Variables with Sodium Thiopental and Propofol as Induction Agents for Cesarean Section

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