Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series

Fen Pan,1,2 Da Li,1,2 Xiaojing Wang,3 Shaojia Lu,1,2 Yi Xu,1,2 Manli Huang1,2 1Department of Mental Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management o...

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Autores principales:	Pan F, Li D, Wang X, Lu S, Xu Y, Huang M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	neuronavigation repetitive transcranial magnetic stimulation depressive adolescents suicidal ideation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ddc31565a0f546b59d77c01417727a88
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spelling	oai:doaj.org-article:ddc31565a0f546b59d77c01417727a882021-12-02T04:15:38ZNeuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series1178-2021https://doaj.org/article/ddc31565a0f546b59d77c01417727a882018-10-01T00:00:00Zhttps://www.dovepress.com/neuronavigation-guided-high-dose-repetitive-transcranial-magnetic-stim-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fen Pan,1,2 Da Li,1,2 Xiaojing Wang,3 Shaojia Lu,1,2 Yi Xu,1,2 Manli Huang1,2 1Department of Mental Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou 310003, People’s Republic of China; 3School of Medicine, Zhejiang University, Hangzhou 310000, People’s Republic of China Background: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder. Case: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found. Conclusion: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required. Keywords: neuronavigation, repetitive transcranial magnetic stimulation, depressive adolescents, suicidal ideationPan FLi DWang XLu SXu YHuang MDove Medical Pressarticleneuronavigationrepetitive transcranial magnetic stimulationdepressive adolescentssuicidal ideationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2675-2679 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuronavigation repetitive transcranial magnetic stimulation depressive adolescents suicidal ideation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neuronavigation repetitive transcranial magnetic stimulation depressive adolescents suicidal ideation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pan F Li D Wang X Lu S Xu Y Huang M Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
description	Fen Pan,1,2 Da Li,1,2 Xiaojing Wang,3 Shaojia Lu,1,2 Yi Xu,1,2 Manli Huang1,2 1Department of Mental Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou 310003, People’s Republic of China; 3School of Medicine, Zhejiang University, Hangzhou 310000, People’s Republic of China Background: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder. Case: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found. Conclusion: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required. Keywords: neuronavigation, repetitive transcranial magnetic stimulation, depressive adolescents, suicidal ideation
format	article
author	Pan F Li D Wang X Lu S Xu Y Huang M
author_facet	Pan F Li D Wang X Lu S Xu Y Huang M
author_sort	Pan F
title	Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_short	Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_full	Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_fullStr	Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_full_unstemmed	Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_sort	neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/ddc31565a0f546b59d77c01417727a88
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Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series

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