3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia

The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.

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Autores principales:	Lu Yang, Fengling Chen, Haichuan Zhu, Yang Chen, Bingjie Dong, Minglei Shi, Weitao Wang, Qian Jiang, Leping Zhang, Xiaojun Huang, Michael Q. Zhang, Hong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddc781751c044fe08a87e5cf4dd8d817
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spelling	oai:doaj.org-article:ddc781751c044fe08a87e5cf4dd8d8172021-12-02T17:40:00Z3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia10.1038/s41467-021-24044-52041-1723https://doaj.org/article/ddc781751c044fe08a87e5cf4dd8d8172021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24044-5https://doaj.org/toc/2041-1723The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.Lu YangFengling ChenHaichuan ZhuYang ChenBingjie DongMinglei ShiWeitao WangQian JiangLeping ZhangXiaojun HuangMichael Q. ZhangHong WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Yang Fengling Chen Haichuan Zhu Yang Chen Bingjie Dong Minglei Shi Weitao Wang Qian Jiang Leping Zhang Xiaojun Huang Michael Q. Zhang Hong Wu 3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
description	The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.
format	article
author	Lu Yang Fengling Chen Haichuan Zhu Yang Chen Bingjie Dong Minglei Shi Weitao Wang Qian Jiang Leping Zhang Xiaojun Huang Michael Q. Zhang Hong Wu
author_facet	Lu Yang Fengling Chen Haichuan Zhu Yang Chen Bingjie Dong Minglei Shi Weitao Wang Qian Jiang Leping Zhang Xiaojun Huang Michael Q. Zhang Hong Wu
author_sort	Lu Yang
title	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
title_short	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
title_full	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
title_fullStr	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
title_full_unstemmed	3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
title_sort	3d genome alterations associated with dysregulated hoxa13 expression in high-risk t-lineage acute lymphoblastic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddc781751c044fe08a87e5cf4dd8d817
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3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia

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