Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.

A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were...

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Autores principales:	Alberto Pondja, Luís Neves, James Mlangwa, Sónia Afonso, José Fafetine, Arve Lee Willingham, Stig Milan Thamsborg, Maria Vang Johansen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ddce2d02381749d795362acd76764253
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spelling	oai:doaj.org-article:ddce2d02381749d795362acd767642532021-11-18T09:14:10ZUse of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.1935-27271935-273510.1371/journal.pntd.0001651https://doaj.org/article/ddce2d02381749d795362acd767642532012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666509/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were selected and assigned randomly to OFZ treatment or control groups. Fifty-four piglets were treated at 4 months of age (T1), while another 54 piglets were treated at 9 months of age (T2) and these were matched with 108 control pigs from the same litters and raised under the same conditions. Baseline data were collected on the prevalence of porcine cysticercosis using antigen ELISA (Ag-ELISA), as well as knowledge and practices related to Taenia solium transmission based on questionnaire interviews and observations. All animals were followed and re-tested for porcine cysticercosis by Ag-ELISA at 9 and 12 months of age when the study was terminated. Overall prevalence at baseline was 5.1% with no significant difference between groups. At the end of the study, 66.7% of the controls were found positive, whereas 21.4% of the T1 and 9.1% of the T2 pigs were positive, respectively. Incidence rates of porcine cysticercosis were lower in treated pigs as compared to controls. Necropsy of 30 randomly selected animals revealed that viable cysts were present in none (0/8) of T2 pigs, 12.5% (1/8) of T1 pigs and 42.8% (6/14) of control pigs. There was a significant reduction in the risk of T. solium cysticercosis if pigs were treated with OFZ either at 4 months (OR = 0.14; 95% CI: 0.05-0.36) or at 9 months of age (OR = 0.05; 95% CI: 0.02-0.16). Strategic treatment of pigs in endemic areas should be further explored as a means to control T. solium cysticercosis/taeniosis.Alberto PondjaLuís NevesJames MlangwaSónia AfonsoJosé FafetineArve Lee WillinghamStig Milan ThamsborgMaria Vang JohansenPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1651 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
description	A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were selected and assigned randomly to OFZ treatment or control groups. Fifty-four piglets were treated at 4 months of age (T1), while another 54 piglets were treated at 9 months of age (T2) and these were matched with 108 control pigs from the same litters and raised under the same conditions. Baseline data were collected on the prevalence of porcine cysticercosis using antigen ELISA (Ag-ELISA), as well as knowledge and practices related to Taenia solium transmission based on questionnaire interviews and observations. All animals were followed and re-tested for porcine cysticercosis by Ag-ELISA at 9 and 12 months of age when the study was terminated. Overall prevalence at baseline was 5.1% with no significant difference between groups. At the end of the study, 66.7% of the controls were found positive, whereas 21.4% of the T1 and 9.1% of the T2 pigs were positive, respectively. Incidence rates of porcine cysticercosis were lower in treated pigs as compared to controls. Necropsy of 30 randomly selected animals revealed that viable cysts were present in none (0/8) of T2 pigs, 12.5% (1/8) of T1 pigs and 42.8% (6/14) of control pigs. There was a significant reduction in the risk of T. solium cysticercosis if pigs were treated with OFZ either at 4 months (OR = 0.14; 95% CI: 0.05-0.36) or at 9 months of age (OR = 0.05; 95% CI: 0.02-0.16). Strategic treatment of pigs in endemic areas should be further explored as a means to control T. solium cysticercosis/taeniosis.
format	article
author	Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen
author_facet	Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen
author_sort	Alberto Pondja
title	Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
title_short	Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
title_full	Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
title_fullStr	Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
title_full_unstemmed	Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
title_sort	use of oxfendazole to control porcine cysticercosis in a high-endemic area of mozambique.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ddce2d02381749d795362acd76764253
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Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.

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