Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.

Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis)...

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Autores principales:	Jing Wang, Anping Chai, Qixin Zhou, Longbao Lv, Liping Wang, Yuexiong Yang, Lin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ddd27012caf04d8bb46943e8eb77c2a6
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spelling	oai:doaj.org-article:ddd27012caf04d8bb46943e8eb77c2a62021-11-18T08:43:59ZChronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.1932-620310.1371/journal.pone.0080980https://doaj.org/article/ddd27012caf04d8bb46943e8eb77c2a62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312510/?tool=EBIhttps://doaj.org/toc/1932-6203Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-established model of the behavioral, endocrine, and neurobiological changes associated with stress-induced depression. The tricyclic antidepressant clomipramine treats many of the core symptoms of depression in humans. To further test the validity of the tree shrew model of depression, we examined the effects of clomipramine on depression-like behaviors and physiological stress responses induced by social defeat in subordinate tree shrews. Social defeat led to weight loss, anhedonia (as measured by sucrose preference), unstable fluctuations in locomotor activity, sustained urinary cortisol elevation, irregular cortisol rhythms, and deficient hippocampal long-term potentiation (LTP). Clomipramine ameliorated anhedonia and irregular locomotor activity, and partially rescued the irregular cortisol rhythm. In contrast, weight loss increased, cortisol levels were even higher, and in vitro LTP was still impaired in the clomipramine treatment group. These results demonstrate the unique advantage of the tree shrew social defeat model of depression.Jing WangAnping ChaiQixin ZhouLongbao LvLiping WangYuexiong YangLin XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80980 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
description	Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-established model of the behavioral, endocrine, and neurobiological changes associated with stress-induced depression. The tricyclic antidepressant clomipramine treats many of the core symptoms of depression in humans. To further test the validity of the tree shrew model of depression, we examined the effects of clomipramine on depression-like behaviors and physiological stress responses induced by social defeat in subordinate tree shrews. Social defeat led to weight loss, anhedonia (as measured by sucrose preference), unstable fluctuations in locomotor activity, sustained urinary cortisol elevation, irregular cortisol rhythms, and deficient hippocampal long-term potentiation (LTP). Clomipramine ameliorated anhedonia and irregular locomotor activity, and partially rescued the irregular cortisol rhythm. In contrast, weight loss increased, cortisol levels were even higher, and in vitro LTP was still impaired in the clomipramine treatment group. These results demonstrate the unique advantage of the tree shrew social defeat model of depression.
format	article
author	Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu
author_facet	Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu
author_sort	Jing Wang
title	Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
title_short	Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
title_full	Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
title_fullStr	Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
title_full_unstemmed	Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
title_sort	chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ddd27012caf04d8bb46943e8eb77c2a6
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Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.

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