Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes

Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal ba...

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Autores principales:	Alena Ivashenka, Christian Wunder, Valerie Chambon, Roger Sandhoff, Richard Jennemann, Estelle Dransart, Katrina Podsypanina, Bérangère Lombard, Damarys Loew, Christophe Lamaze, Francoise Poirier, Hermann-Josef Gröne, Ludger Johannes, Massiullah Shafaq-Zadah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ddd280be10104d1db4c00ab5b1dd138b
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spelling	oai:doaj.org-article:ddd280be10104d1db4c00ab5b1dd138b2021-12-02T14:11:03ZGlycolipid-dependent and lectin-driven transcytosis in mouse enterocytes10.1038/s42003-021-01693-22399-3642https://doaj.org/article/ddd280be10104d1db4c00ab5b1dd138b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01693-2https://doaj.org/toc/2399-3642Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal barrier relies on this glycolipid and lectin (GL-Lect)-mediated endocytosis.Alena IvashenkaChristian WunderValerie ChambonRoger SandhoffRichard JennemannEstelle DransartKatrina PodsypaninaBérangère LombardDamarys LoewChristophe LamazeFrancoise PoirierHermann-Josef GröneLudger JohannesMassiullah Shafaq-ZadahNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alena Ivashenka Christian Wunder Valerie Chambon Roger Sandhoff Richard Jennemann Estelle Dransart Katrina Podsypanina Bérangère Lombard Damarys Loew Christophe Lamaze Francoise Poirier Hermann-Josef Gröne Ludger Johannes Massiullah Shafaq-Zadah Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
description	Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal barrier relies on this glycolipid and lectin (GL-Lect)-mediated endocytosis.
format	article
author	Alena Ivashenka Christian Wunder Valerie Chambon Roger Sandhoff Richard Jennemann Estelle Dransart Katrina Podsypanina Bérangère Lombard Damarys Loew Christophe Lamaze Francoise Poirier Hermann-Josef Gröne Ludger Johannes Massiullah Shafaq-Zadah
author_facet	Alena Ivashenka Christian Wunder Valerie Chambon Roger Sandhoff Richard Jennemann Estelle Dransart Katrina Podsypanina Bérangère Lombard Damarys Loew Christophe Lamaze Francoise Poirier Hermann-Josef Gröne Ludger Johannes Massiullah Shafaq-Zadah
author_sort	Alena Ivashenka
title	Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
title_short	Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
title_full	Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
title_fullStr	Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
title_full_unstemmed	Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
title_sort	glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddd280be10104d1db4c00ab5b1dd138b
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Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes

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