Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages.

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Autores principales: Li Zhao, Shumei Wang, Meng Xu, Yang He, Xiaowei Zhang, Ying Xiong, Hong Sun, Haibo Ding, Wenqing Geng, Hong Shang, Guoxin Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ddd5c835dbf9457c830d0075ef2284e0
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spelling oai:doaj.org-article:ddd5c835dbf9457c830d0075ef2284e02021-12-02T17:40:25ZVpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages10.1038/s41467-021-24087-82041-1723https://doaj.org/article/ddd5c835dbf9457c830d0075ef2284e02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24087-8https://doaj.org/toc/2041-1723Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages.Li ZhaoShumei WangMeng XuYang HeXiaowei ZhangYing XiongHong SunHaibo DingWenqing GengHong ShangGuoxin LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Li Zhao
Shumei Wang
Meng Xu
Yang He
Xiaowei Zhang
Ying Xiong
Hong Sun
Haibo Ding
Wenqing Geng
Hong Shang
Guoxin Liang
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
description Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages.
format article
author Li Zhao
Shumei Wang
Meng Xu
Yang He
Xiaowei Zhang
Ying Xiong
Hong Sun
Haibo Ding
Wenqing Geng
Hong Shang
Guoxin Liang
author_facet Li Zhao
Shumei Wang
Meng Xu
Yang He
Xiaowei Zhang
Ying Xiong
Hong Sun
Haibo Ding
Wenqing Geng
Hong Shang
Guoxin Liang
author_sort Li Zhao
title Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
title_short Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
title_full Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
title_fullStr Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
title_full_unstemmed Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
title_sort vpr counteracts the restriction of laptm5 to promote hiv-1 infection in macrophages
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ddd5c835dbf9457c830d0075ef2284e0
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