Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages.

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Autores principales: Li Zhao, Shumei Wang, Meng Xu, Yang He, Xiaowei Zhang, Ying Xiong, Hong Sun, Haibo Ding, Wenqing Geng, Hong Shang, Guoxin Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/ddd5c835dbf9457c830d0075ef2284e0
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