In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neu...

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Autores principales: Andreas H. Laustsen, Aneesh Karatt-Vellatt, Edward W. Masters, Ana Silvia Arias, Urska Pus, Cecilie Knudsen, Saioa Oscoz, Peter Slavny, Daniel T. Griffiths, Alice M. Luther, Rachael A. Leah, Majken Lindholm, Bruno Lomonte, José María Gutiérrez, John McCafferty
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ddd6fff5db93422e9ee2acd780659e94
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spelling oai:doaj.org-article:ddd6fff5db93422e9ee2acd780659e942021-12-02T15:34:08ZIn vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies10.1038/s41467-018-06086-42041-1723https://doaj.org/article/ddd6fff5db93422e9ee2acd780659e942018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06086-4https://doaj.org/toc/2041-1723Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neutralizing dendrotoxin-mediated neurotoxicity using venom challenge in vivo models.Andreas H. LaustsenAneesh Karatt-VellattEdward W. MastersAna Silvia AriasUrska PusCecilie KnudsenSaioa OscozPeter SlavnyDaniel T. GriffithsAlice M. LutherRachael A. LeahMajken LindholmBruno LomonteJosé María GutiérrezJohn McCaffertyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andreas H. Laustsen
Aneesh Karatt-Vellatt
Edward W. Masters
Ana Silvia Arias
Urska Pus
Cecilie Knudsen
Saioa Oscoz
Peter Slavny
Daniel T. Griffiths
Alice M. Luther
Rachael A. Leah
Majken Lindholm
Bruno Lomonte
José María Gutiérrez
John McCafferty
In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
description Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neutralizing dendrotoxin-mediated neurotoxicity using venom challenge in vivo models.
format article
author Andreas H. Laustsen
Aneesh Karatt-Vellatt
Edward W. Masters
Ana Silvia Arias
Urska Pus
Cecilie Knudsen
Saioa Oscoz
Peter Slavny
Daniel T. Griffiths
Alice M. Luther
Rachael A. Leah
Majken Lindholm
Bruno Lomonte
José María Gutiérrez
John McCafferty
author_facet Andreas H. Laustsen
Aneesh Karatt-Vellatt
Edward W. Masters
Ana Silvia Arias
Urska Pus
Cecilie Knudsen
Saioa Oscoz
Peter Slavny
Daniel T. Griffiths
Alice M. Luther
Rachael A. Leah
Majken Lindholm
Bruno Lomonte
José María Gutiérrez
John McCafferty
author_sort Andreas H. Laustsen
title In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
title_short In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
title_full In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
title_fullStr In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
title_full_unstemmed In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
title_sort in vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human igg antibodies
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ddd6fff5db93422e9ee2acd780659e94
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