RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expr...
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Nature Portfolio
2019
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oai:doaj.org-article:ddd72678135941fdb84362715749b1f12021-12-02T16:57:45ZRORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients10.1038/s41467-018-07911-62041-1723https://doaj.org/article/ddd72678135941fdb84362715749b1f12019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07911-6https://doaj.org/toc/2041-1723The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael TurnerSofie Van GassenLiesbet MartensDustin SmithChristian HarckenJoseph WahleChao-Ting WangEveline VerheugenNadia SchryversGaëlle VarkasHeleen CypersRuth WittoekYves PietteLieve GyselbrechtSerge Van CalenberghFilip Van den BoschYvan SaeysGerald NaboznyDirk ElewautNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| description |
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints. |
| format |
article |
| author |
Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut |
| author_facet |
Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut |
| author_sort |
Koen Venken |
| title |
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_short |
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_full |
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_fullStr |
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_full_unstemmed |
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_sort |
rorγt inhibition selectively targets il-17 producing inkt and γδ-t cells enriched in spondyloarthritis patients |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ddd72678135941fdb84362715749b1f1 |
| work_keys_str_mv |
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