Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle, show that Bcan-Ntrk1 fusion leads to glioblast...

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Autores principales:	Peter J. Cook, Rozario Thomas, Ram Kannan, Esther Sanchez de Leon, Alexander Drilon, Marc K. Rosenblum, Maurizio Scaltriti, Robert Benezra, Andrea Ventura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddd7582963914757848181c6d8b5e60f
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spelling	oai:doaj.org-article:ddd7582963914757848181c6d8b5e60f2021-12-02T17:01:25ZSomatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target10.1038/ncomms159872041-1723https://doaj.org/article/ddd7582963914757848181c6d8b5e60f2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15987https://doaj.org/toc/2041-1723The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle, show that Bcan-Ntrk1 fusion leads to glioblastomas.Peter J. CookRozario ThomasRam KannanEsther Sanchez de LeonAlexander DrilonMarc K. RosenblumMaurizio ScaltritiRobert BenezraAndrea VenturaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter J. Cook Rozario Thomas Ram Kannan Esther Sanchez de Leon Alexander Drilon Marc K. Rosenblum Maurizio Scaltriti Robert Benezra Andrea Ventura Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
description	The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle, show that Bcan-Ntrk1 fusion leads to glioblastomas.
format	article
author	Peter J. Cook Rozario Thomas Ram Kannan Esther Sanchez de Leon Alexander Drilon Marc K. Rosenblum Maurizio Scaltriti Robert Benezra Andrea Ventura
author_facet	Peter J. Cook Rozario Thomas Ram Kannan Esther Sanchez de Leon Alexander Drilon Marc K. Rosenblum Maurizio Scaltriti Robert Benezra Andrea Ventura
author_sort	Peter J. Cook
title	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
title_short	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
title_full	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
title_fullStr	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
title_full_unstemmed	Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
title_sort	somatic chromosomal engineering identifies bcan-ntrk1 as a potent glioma driver and therapeutic target
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ddd7582963914757848181c6d8b5e60f
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Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

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