Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease

Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005–2019 was used for this analysis. Hospitalized PAD patients were stratifi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karsten Keller, Volker H. Schmitt, Markus Vosseler, Christoph Brochhausen, Thomas Münzel, Lukas Hobohm, Christine Espinola-Klein
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus peripheral artery disease myocardial infarction amputation Medicine R
Acceso en línea:	https://doaj.org/article/dddb60057b2c4128bc3737667e03c44b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dddb60057b2c4128bc3737667e03c44b
record_format	dspace
spelling	oai:doaj.org-article:dddb60057b2c4128bc3737667e03c44b2021-11-11T17:39:29ZDiabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease10.3390/jcm102150332077-0383https://doaj.org/article/dddb60057b2c4128bc3737667e03c44b2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5033https://doaj.org/toc/2077-0383Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005–2019 was used for this analysis. Hospitalized PAD patients were stratified for DM and the influence of DM on patient-profile and adverse in-hospital events was investigated. Results: Our study comprised 2,654,871 hospitalizations (54.3% aged ≥70 years, 36.7% females) of patients with PAD in Germany 2005–2019. Among these, 864,691 (32.6%) patients had DM and 76,716 (2.9%) died during hospitalization. Diabetic PAD patients revealed an aggravated cardiovascular profile (Charlson Comorbidity Index: 6.0 (5.0–8.0) vs. 4.0 (3.0–5.0), <i>p</i> < 0.001). PAD patients with DM showed a higher rate of in-hospital mortality (3.5% vs. 2.6%, <i>p</i> < 0.001), as well as major adverse cardiovascular and cerebrovascular events (MACCE, 4.7% vs. 3.3%, <i>p</i> < 0.001) and had more often operated with amputation surgery (16.4% vs. 9.1%, <i>p</i> < 0.001). DM was an independent predictor of in-hospital mortality (OR 1.077 (95%CI 1.060–1.093), <i>p</i> < 0.001) and MACCE (OR 1.118 (95%CI 1.103–1.133), <i>p</i> < 0.001). In addition, amputations were also associated with DM (OR 1.804 (95%CI 1.790–1.818)), <i>p</i> < 0.001). Conclusions: DM is associated with an unfavorable clinical patient-profile and higher risk for adverse events in PAD patients, including substantially increased in-hospital mortality as well as MACCE rate, and were more often associated with amputation surgeries.Karsten KellerVolker H. SchmittMarkus VosselerChristoph BrochhausenThomas MünzelLukas HobohmChristine Espinola-KleinMDPI AGarticlediabetes mellitusperipheral artery diseasemyocardial infarctionamputationMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5033, p 5033 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus peripheral artery disease myocardial infarction amputation Medicine R
spellingShingle	diabetes mellitus peripheral artery disease myocardial infarction amputation Medicine R Karsten Keller Volker H. Schmitt Markus Vosseler Christoph Brochhausen Thomas Münzel Lukas Hobohm Christine Espinola-Klein Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
description	Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005–2019 was used for this analysis. Hospitalized PAD patients were stratified for DM and the influence of DM on patient-profile and adverse in-hospital events was investigated. Results: Our study comprised 2,654,871 hospitalizations (54.3% aged ≥70 years, 36.7% females) of patients with PAD in Germany 2005–2019. Among these, 864,691 (32.6%) patients had DM and 76,716 (2.9%) died during hospitalization. Diabetic PAD patients revealed an aggravated cardiovascular profile (Charlson Comorbidity Index: 6.0 (5.0–8.0) vs. 4.0 (3.0–5.0), <i>p</i> < 0.001). PAD patients with DM showed a higher rate of in-hospital mortality (3.5% vs. 2.6%, <i>p</i> < 0.001), as well as major adverse cardiovascular and cerebrovascular events (MACCE, 4.7% vs. 3.3%, <i>p</i> < 0.001) and had more often operated with amputation surgery (16.4% vs. 9.1%, <i>p</i> < 0.001). DM was an independent predictor of in-hospital mortality (OR 1.077 (95%CI 1.060–1.093), <i>p</i> < 0.001) and MACCE (OR 1.118 (95%CI 1.103–1.133), <i>p</i> < 0.001). In addition, amputations were also associated with DM (OR 1.804 (95%CI 1.790–1.818)), <i>p</i> < 0.001). Conclusions: DM is associated with an unfavorable clinical patient-profile and higher risk for adverse events in PAD patients, including substantially increased in-hospital mortality as well as MACCE rate, and were more often associated with amputation surgeries.
format	article
author	Karsten Keller Volker H. Schmitt Markus Vosseler Christoph Brochhausen Thomas Münzel Lukas Hobohm Christine Espinola-Klein
author_facet	Karsten Keller Volker H. Schmitt Markus Vosseler Christoph Brochhausen Thomas Münzel Lukas Hobohm Christine Espinola-Klein
author_sort	Karsten Keller
title	Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
title_short	Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
title_full	Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
title_fullStr	Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
title_full_unstemmed	Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease
title_sort	diabetes mellitus and its impact on patient-profile and in-hospital outcomes in peripheral artery disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dddb60057b2c4128bc3737667e03c44b
work_keys_str_mv	AT karstenkeller diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT volkerhschmitt diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT markusvosseler diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT christophbrochhausen diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT thomasmunzel diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT lukashobohm diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease AT christineespinolaklein diabetesmellitusanditsimpactonpatientprofileandinhospitaloutcomesinperipheralarterydisease
_version_	1718432030464671744

Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease

Ejemplares similares