Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)

The xrRNA1 RNA from ZIKA virus (ZIKV) forms a complex ring-like architecture and is known for its mechanical anisotropy, but the mechanism for its direction-dependent mechanical responses remain unclear. Here authors use a single-molecule nanopore sensing technique combined with molecular dynamics s...

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Autores principales:	Xiaolin Niu, Qiuhan Liu, Zhonghe Xu, Zhifeng Chen, Linghui Xu, Lilei Xu, Jinghong Li, Xianyang Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddddac9742724272becb5170dabf6c4a
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spelling	oai:doaj.org-article:ddddac9742724272becb5170dabf6c4a2021-12-02T17:32:44ZMolecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)10.1038/s41467-020-19260-42041-1723https://doaj.org/article/ddddac9742724272becb5170dabf6c4a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19260-4https://doaj.org/toc/2041-1723The xrRNA1 RNA from ZIKA virus (ZIKV) forms a complex ring-like architecture and is known for its mechanical anisotropy, but the mechanism for its direction-dependent mechanical responses remain unclear. Here authors use a single-molecule nanopore sensing technique combined with molecular dynamics simulations and show that the anisotropy in ZIKV xrRNA1 depends on Mg2+ and the key tertiary interactions.Xiaolin NiuQiuhan LiuZhonghe XuZhifeng ChenLinghui XuLilei XuJinghong LiXianyang FangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolin Niu Qiuhan Liu Zhonghe Xu Zhifeng Chen Linghui Xu Lilei Xu Jinghong Li Xianyang Fang Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
description	The xrRNA1 RNA from ZIKA virus (ZIKV) forms a complex ring-like architecture and is known for its mechanical anisotropy, but the mechanism for its direction-dependent mechanical responses remain unclear. Here authors use a single-molecule nanopore sensing technique combined with molecular dynamics simulations and show that the anisotropy in ZIKV xrRNA1 depends on Mg2+ and the key tertiary interactions.
format	article
author	Xiaolin Niu Qiuhan Liu Zhonghe Xu Zhifeng Chen Linghui Xu Lilei Xu Jinghong Li Xianyang Fang
author_facet	Xiaolin Niu Qiuhan Liu Zhonghe Xu Zhifeng Chen Linghui Xu Lilei Xu Jinghong Li Xianyang Fang
author_sort	Xiaolin Niu
title	Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
title_short	Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
title_full	Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
title_fullStr	Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
title_full_unstemmed	Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)
title_sort	molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant rnas (xrrnas)
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ddddac9742724272becb5170dabf6c4a
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Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)

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