A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm
ABSTRACT The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The...
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American Society for Microbiology
2011
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oai:doaj.org-article:dde116ed01854747981ed4cca0c19a972021-11-15T15:38:47ZA Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm10.1128/mBio.00325-102150-7511https://doaj.org/article/dde116ed01854747981ed4cca0c19a972011-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00325-10https://doaj.org/toc/2150-7511ABSTRACT The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.Alan AderemJoshua N. AdkinsCharles AnsongJames GalaganShari KaiserMarcus J. KorthG. Lynn LawJason G. McDermottSean C. ProllCarrie RosenbergerGary SchoolnikMichael G. KatzeAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 1 (2011) |
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DOAJ |
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EN |
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Microbiology QR1-502 |
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Microbiology QR1-502 Alan Aderem Joshua N. Adkins Charles Ansong James Galagan Shari Kaiser Marcus J. Korth G. Lynn Law Jason G. McDermott Sean C. Proll Carrie Rosenberger Gary Schoolnik Michael G. Katze A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| description |
ABSTRACT The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm. |
| format |
article |
| author |
Alan Aderem Joshua N. Adkins Charles Ansong James Galagan Shari Kaiser Marcus J. Korth G. Lynn Law Jason G. McDermott Sean C. Proll Carrie Rosenberger Gary Schoolnik Michael G. Katze |
| author_facet |
Alan Aderem Joshua N. Adkins Charles Ansong James Galagan Shari Kaiser Marcus J. Korth G. Lynn Law Jason G. McDermott Sean C. Proll Carrie Rosenberger Gary Schoolnik Michael G. Katze |
| author_sort |
Alan Aderem |
| title |
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| title_short |
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| title_full |
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| title_fullStr |
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| title_full_unstemmed |
A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm |
| title_sort |
systems biology approach to infectious disease research: innovating the pathogen-host research paradigm |
| publisher |
American Society for Microbiology |
| publishDate |
2011 |
| url |
https://doaj.org/article/dde116ed01854747981ed4cca0c19a97 |
| work_keys_str_mv |
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