Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals

Antidepressants are extensively used to treat the symptoms of depression in humans, and the environmentally discharged drugs potentially threaten aquatic organisms. In this study, the acute toxic effects of fluoxetine (FLX) were investigated in two aquatic organisms, the freshwater polyp (Hydra magn...

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Autores principales:	Ade Yamindago, Nayun Lee, Nayoung Lee, Yejin Jo, Seonock Woo, Seungshic Yum
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antidepressant Behavioral effects Transcriptomics Microarray probe Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/dde3ea7de25346b4bdda8d800ac636e5
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spelling	oai:doaj.org-article:dde3ea7de25346b4bdda8d800ac636e52021-11-06T04:18:07ZFluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals0147-651310.1016/j.ecoenv.2021.112931https://doaj.org/article/dde3ea7de25346b4bdda8d800ac636e52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010435https://doaj.org/toc/0147-6513Antidepressants are extensively used to treat the symptoms of depression in humans, and the environmentally discharged drugs potentially threaten aquatic organisms. In this study, the acute toxic effects of fluoxetine (FLX) were investigated in two aquatic organisms, the freshwater polyp (Hydra magnipapillata) and Javanese medaka (Oryzias javanicus). The median lethal concentration (LC50) of FLX in H. magnipapillata was 3.678, 3.082, and 2.901 mg/L after 24, 48, and 72 h, respectively. Morphological observations of the FLX-exposed H. magnipapillata showed that 1.5 mg/L FLX induced the contraction of the tentacles and body column. The LC50 of FLX in O. javanicus was 2.046, 1.936, 1.532, and 1.237 mg/L after 24, 48, 72, and 96 h, respectively. Observation of the behavior of the FLX-exposed fish showed that FLX reduced their swimming performance at a minimum concentration of 10 µg/L. The half-maximal effective concentration (EC50) of FLX for swimming behavior in O. javanicus was 0.135, 0.108, and 0.011 mg/L after 12, 24, and 96 h, respectively. Transcriptomic analyses indicated that FLX affects various physiological and metabolic processes in both species. FLX exposure induced oxidative stress, reproductive deficiency, abnormal pattern formation, DNA damage, and neurotransmission disturbance in H. magnipapillata, whereas it adversely affected O. javanicus by inducing oxidative stress, DNA damage, endoplasmic reticulum stress, and mRNA instability. Neurotransmission-based behavioral changes and endocrine disruption were strongly suspected in the FLX-exposed fish. These results suggest that FLX affects the behavior and metabolic regulation of aquatic organisms.Ade YamindagoNayun LeeNayoung LeeYejin JoSeonock WooSeungshic YumElsevierarticleAntidepressantBehavioral effectsTranscriptomicsMicroarray probeEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112931- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antidepressant Behavioral effects Transcriptomics Microarray probe Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Antidepressant Behavioral effects Transcriptomics Microarray probe Environmental pollution TD172-193.5 Environmental sciences GE1-350 Ade Yamindago Nayun Lee Nayoung Lee Yejin Jo Seonock Woo Seungshic Yum Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
description	Antidepressants are extensively used to treat the symptoms of depression in humans, and the environmentally discharged drugs potentially threaten aquatic organisms. In this study, the acute toxic effects of fluoxetine (FLX) were investigated in two aquatic organisms, the freshwater polyp (Hydra magnipapillata) and Javanese medaka (Oryzias javanicus). The median lethal concentration (LC50) of FLX in H. magnipapillata was 3.678, 3.082, and 2.901 mg/L after 24, 48, and 72 h, respectively. Morphological observations of the FLX-exposed H. magnipapillata showed that 1.5 mg/L FLX induced the contraction of the tentacles and body column. The LC50 of FLX in O. javanicus was 2.046, 1.936, 1.532, and 1.237 mg/L after 24, 48, 72, and 96 h, respectively. Observation of the behavior of the FLX-exposed fish showed that FLX reduced their swimming performance at a minimum concentration of 10 µg/L. The half-maximal effective concentration (EC50) of FLX for swimming behavior in O. javanicus was 0.135, 0.108, and 0.011 mg/L after 12, 24, and 96 h, respectively. Transcriptomic analyses indicated that FLX affects various physiological and metabolic processes in both species. FLX exposure induced oxidative stress, reproductive deficiency, abnormal pattern formation, DNA damage, and neurotransmission disturbance in H. magnipapillata, whereas it adversely affected O. javanicus by inducing oxidative stress, DNA damage, endoplasmic reticulum stress, and mRNA instability. Neurotransmission-based behavioral changes and endocrine disruption were strongly suspected in the FLX-exposed fish. These results suggest that FLX affects the behavior and metabolic regulation of aquatic organisms.
format	article
author	Ade Yamindago Nayun Lee Nayoung Lee Yejin Jo Seonock Woo Seungshic Yum
author_facet	Ade Yamindago Nayun Lee Nayoung Lee Yejin Jo Seonock Woo Seungshic Yum
author_sort	Ade Yamindago
title	Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
title_short	Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
title_full	Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
title_fullStr	Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
title_full_unstemmed	Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
title_sort	fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dde3ea7de25346b4bdda8d800ac636e5
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Fluoxetine in the environment may interfere with the neurotransmission or endocrine systems of aquatic animals

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