Prediction of anemia at delivery

Abstract We aimed to assess risk factors for anemia at delivery by conducting a secondary analysis of a prospective cohort study database including 1527 women who delivered vaginally ≥ 36 gestational weeks. Anemia (Hemoglobin (Hb) < 10.5 g/dL) was assessed at delivery. A complete blood count resu...

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Autores principales:	Enav Yefet, Avishag Yossef, Zohar Nachum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dde81d4f091c416090fce05ba60cd53c
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spelling	oai:doaj.org-article:dde81d4f091c416090fce05ba60cd53c2021-12-02T17:05:11ZPrediction of anemia at delivery10.1038/s41598-021-85622-72045-2322https://doaj.org/article/dde81d4f091c416090fce05ba60cd53c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85622-7https://doaj.org/toc/2045-2322Abstract We aimed to assess risk factors for anemia at delivery by conducting a secondary analysis of a prospective cohort study database including 1527 women who delivered vaginally ≥ 36 gestational weeks. Anemia (Hemoglobin (Hb) < 10.5 g/dL) was assessed at delivery. A complete blood count results during pregnancy as well as maternal and obstetrical characteristics were collected. The primary endpoint was to determine the Hb cutoff between 24 and 30 gestational weeks that is predictive of anemia at delivery by using the area under the curve (AUC) of the receiver operating characteristic curve. Independent risk factors for anemia at delivery were assessed using stepwise multivariable logistic regression. Hb and infrequent iron supplement treatment were independent risk factors for anemia at delivery (OR 0.3 95%CI [0.2–0.4] and OR 2.4 95%CI [1.2–4.8], respectively; C statistics 83%). Hb 10.6 g/dL was an accurate cutoff to predict anemia at delivery (AUC 80% 95%CI 75–84%; sensitivity 75% and specificity 74%). Iron supplement was beneficial to prevent anemia regardless of Hb value. Altogether, Hb should be routinely tested between 24 and 30 gestational weeks to screen for anemia. A flow chart for anemia screening and treatment during pregnancy is proposed in the manuscript. Trial registration: ClinicalTrials.gov Identifier: NCT02434653.Enav YefetAvishag YossefZohar NachumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enav Yefet Avishag Yossef Zohar Nachum Prediction of anemia at delivery
description	Abstract We aimed to assess risk factors for anemia at delivery by conducting a secondary analysis of a prospective cohort study database including 1527 women who delivered vaginally ≥ 36 gestational weeks. Anemia (Hemoglobin (Hb) < 10.5 g/dL) was assessed at delivery. A complete blood count results during pregnancy as well as maternal and obstetrical characteristics were collected. The primary endpoint was to determine the Hb cutoff between 24 and 30 gestational weeks that is predictive of anemia at delivery by using the area under the curve (AUC) of the receiver operating characteristic curve. Independent risk factors for anemia at delivery were assessed using stepwise multivariable logistic regression. Hb and infrequent iron supplement treatment were independent risk factors for anemia at delivery (OR 0.3 95%CI [0.2–0.4] and OR 2.4 95%CI [1.2–4.8], respectively; C statistics 83%). Hb 10.6 g/dL was an accurate cutoff to predict anemia at delivery (AUC 80% 95%CI 75–84%; sensitivity 75% and specificity 74%). Iron supplement was beneficial to prevent anemia regardless of Hb value. Altogether, Hb should be routinely tested between 24 and 30 gestational weeks to screen for anemia. A flow chart for anemia screening and treatment during pregnancy is proposed in the manuscript. Trial registration: ClinicalTrials.gov Identifier: NCT02434653.
format	article
author	Enav Yefet Avishag Yossef Zohar Nachum
author_facet	Enav Yefet Avishag Yossef Zohar Nachum
author_sort	Enav Yefet
title	Prediction of anemia at delivery
title_short	Prediction of anemia at delivery
title_full	Prediction of anemia at delivery
title_fullStr	Prediction of anemia at delivery
title_full_unstemmed	Prediction of anemia at delivery
title_sort	prediction of anemia at delivery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dde81d4f091c416090fce05ba60cd53c
work_keys_str_mv	AT enavyefet predictionofanemiaatdelivery AT avishagyossef predictionofanemiaatdelivery AT zoharnachum predictionofanemiaatdelivery
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Prediction of anemia at delivery

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