Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy

Mutations in glycyl-tRNA synthetase (GlyRS) cause Charcot-Marie-Tooth disease, a neuromuscular disorder characterized by axonal degeneration. Here the authors show that mutant GlyRS interacts with histone deacetylase 6, resulting in increased deacetylation of α-tubulin and axonal transport deficits....

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Autores principales:	Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L. Pfaff, C. Thomas Caskey, Chengbiao Wu, Ge Bai, Xiang-Lei Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dde98cded6fc4c8db9679bb17adaa174
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spelling	oai:doaj.org-article:dde98cded6fc4c8db9679bb17adaa1742021-12-02T17:33:02ZAberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy10.1038/s41467-018-03461-z2041-1723https://doaj.org/article/dde98cded6fc4c8db9679bb17adaa1742018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03461-zhttps://doaj.org/toc/2041-1723Mutations in glycyl-tRNA synthetase (GlyRS) cause Charcot-Marie-Tooth disease, a neuromuscular disorder characterized by axonal degeneration. Here the authors show that mutant GlyRS interacts with histone deacetylase 6, resulting in increased deacetylation of α-tubulin and axonal transport deficits.Zhongying MoXiaobei ZhaoHuaqing LiuQinghua HuXu-Qiao ChenJessica PhamNa WeiZe LiuJiadong ZhouRobert W. BurgessSamuel L. PfaffC. Thomas CaskeyChengbiao WuGe BaiXiang-Lei YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongying Mo Xiaobei Zhao Huaqing Liu Qinghua Hu Xu-Qiao Chen Jessica Pham Na Wei Ze Liu Jiadong Zhou Robert W. Burgess Samuel L. Pfaff C. Thomas Caskey Chengbiao Wu Ge Bai Xiang-Lei Yang Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
description	Mutations in glycyl-tRNA synthetase (GlyRS) cause Charcot-Marie-Tooth disease, a neuromuscular disorder characterized by axonal degeneration. Here the authors show that mutant GlyRS interacts with histone deacetylase 6, resulting in increased deacetylation of α-tubulin and axonal transport deficits.
format	article
author	Zhongying Mo Xiaobei Zhao Huaqing Liu Qinghua Hu Xu-Qiao Chen Jessica Pham Na Wei Ze Liu Jiadong Zhou Robert W. Burgess Samuel L. Pfaff C. Thomas Caskey Chengbiao Wu Ge Bai Xiang-Lei Yang
author_facet	Zhongying Mo Xiaobei Zhao Huaqing Liu Qinghua Hu Xu-Qiao Chen Jessica Pham Na Wei Ze Liu Jiadong Zhou Robert W. Burgess Samuel L. Pfaff C. Thomas Caskey Chengbiao Wu Ge Bai Xiang-Lei Yang
author_sort	Zhongying Mo
title	Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
title_short	Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
title_full	Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
title_fullStr	Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
title_full_unstemmed	Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
title_sort	aberrant glyrs-hdac6 interaction linked to axonal transport deficits in charcot-marie-tooth neuropathy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dde98cded6fc4c8db9679bb17adaa174
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Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy

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