Glypican-3 targeted delivery of 89Zr and 90Y as a theranostic radionuclide platform for hepatocellular carcinoma
Abstract Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 conjugated to zirconium-89 (89Zr) and yttrium-90 (90Y) to identify, treat, and ass...
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Autores principales: | Kevin P. Labadie, Andrew D. Ludwig, Adrienne L. Lehnert, Donald K. Hamlin, Aimee L. Kenoyer, Kevin M. Sullivan, Sara K. Daniel, Tara N. Mihailovic, Jonathan G. Sham, Johnnie J. Orozco, Raymond S. Yeung, Delphine L. Chen, D. Scott Wilbur, Robert S. Miyaoka, James O. Park |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/ddea22e7449b4b418c2f02ca24983fd2 |
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