Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management
Aim. To evaluate the efficacy and safety of the novel combined laser treatment technology compared with those of the conventional laser photocoagulation in diabetic macular oedema management. Material and methods. Fifty eyes of 44 patients with clinically significant diabetic macular oedema were en...
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Endocrinology Research Centre
2017
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oai:doaj.org-article:ddec57eac97a47c58a35e8caabf57d192021-11-14T09:00:21ZComparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management2072-03512072-037810.14341/DM7811https://doaj.org/article/ddec57eac97a47c58a35e8caabf57d192017-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7811https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate the efficacy and safety of the novel combined laser treatment technology compared with those of the conventional laser photocoagulation in diabetic macular oedema management. Material and methods. Fifty eyes of 44 patients with clinically significant diabetic macular oedema were enrolled. Patients of the main group (25 eyes) underwent combined laser treatment, whereas patients in the control group (25 eyes) underwent modified ETDRS (mETDRS) focal/grid photocoagulation. Results. Mean central point thickness (CPT) in the main group decreased from 411.24 ± 126 µm to 359.86 ± 120.4 µm (p < 0.05), with a subsequent increase in the mean best-corrected visual acuity (BCVA) from 0.52 ± 0.2 at baseline to 0.71 ± 0.2 (p < 0.05) at the 12-month follow-up. The mean central retinal sensitivity (RS) improved from 11.27 ± 3.8 dB to 13.24 ± 3.2 dB (p < 0.05). In the control group, our results showed similar improvement in BCVA and CPT values at the 12-month follow-up (from 0.59 ± 0.12 to 0.72 ± 0.23 and from 424.17 ± 68.12 µm to 387.51 ± 93.45 µm, respectively, p < 0.05). The RS value, on the contrary, decreased from 12.32 ± 0.90 dB to 10.14 ± 0.71 dB (p < 0.05). Conclusions. The combined laser technology is a safe treatment technique that allows to minimise the extent of laser-induced chorioretinal complex damage due to the contribution of subthreshold micropulse laser photocoagulation. The efficacy of this novel technology is comparable with that of the mETDRS technique in the resolution of macular oedema and BCVA increase. This technology also provides an advantage of RS improvement and the possibility of safe and repetitive treatment sessions.Aleksander Victorovich DogaGalina Fedorovna KachalinaElena Konstantinovna PedanovaDmitry Anatolievich BuryakovEndocrinology Research Centrearticlesubthreshold micropulse yellow laser photocoagulationretinal pigment epitheliumlaser photocoagulationoptical coherence tomographyautofluorescencemicroperimetryNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 1, Pp 68-74 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN RU |
| topic |
subthreshold micropulse yellow laser photocoagulation retinal pigment epithelium laser photocoagulation optical coherence tomography autofluorescence microperimetry Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
subthreshold micropulse yellow laser photocoagulation retinal pigment epithelium laser photocoagulation optical coherence tomography autofluorescence microperimetry Nutritional diseases. Deficiency diseases RC620-627 Aleksander Victorovich Doga Galina Fedorovna Kachalina Elena Konstantinovna Pedanova Dmitry Anatolievich Buryakov Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| description |
Aim. To evaluate the efficacy and safety of the novel combined laser treatment technology compared with those of the conventional laser photocoagulation in diabetic macular oedema management.
Material and methods. Fifty eyes of 44 patients with clinically significant diabetic macular oedema were enrolled. Patients of the main group (25 eyes) underwent combined laser treatment, whereas patients in the control group (25 eyes) underwent modified ETDRS (mETDRS) focal/grid photocoagulation.
Results. Mean central point thickness (CPT) in the main group decreased from 411.24 ± 126 µm to 359.86 ± 120.4 µm (p < 0.05), with a subsequent increase in the mean best-corrected visual acuity (BCVA) from 0.52 ± 0.2 at baseline to 0.71 ± 0.2 (p < 0.05) at the 12-month follow-up. The mean central retinal sensitivity (RS) improved from 11.27 ± 3.8 dB to 13.24 ± 3.2 dB (p < 0.05). In the control group, our results showed similar improvement in BCVA and CPT values at the 12-month follow-up (from 0.59 ± 0.12 to 0.72 ± 0.23 and from 424.17 ± 68.12 µm to 387.51 ± 93.45 µm, respectively, p < 0.05). The RS value, on the contrary, decreased from 12.32 ± 0.90 dB to 10.14 ± 0.71 dB (p < 0.05).
Conclusions. The combined laser technology is a safe treatment technique that allows to minimise the extent of laser-induced chorioretinal complex damage due to the contribution of subthreshold micropulse laser photocoagulation. The efficacy of this novel technology is comparable with that of the mETDRS technique in the resolution of macular oedema and BCVA increase. This technology also provides an advantage of RS improvement and the possibility of safe and repetitive treatment sessions. |
| format |
article |
| author |
Aleksander Victorovich Doga Galina Fedorovna Kachalina Elena Konstantinovna Pedanova Dmitry Anatolievich Buryakov |
| author_facet |
Aleksander Victorovich Doga Galina Fedorovna Kachalina Elena Konstantinovna Pedanova Dmitry Anatolievich Buryakov |
| author_sort |
Aleksander Victorovich Doga |
| title |
Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| title_short |
Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| title_full |
Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| title_fullStr |
Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| title_full_unstemmed |
Comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| title_sort |
comparison of efficacy and safety of the combined laser treatment technology versus conventional laser photocoagulation in diabetic macular edema management |
| publisher |
Endocrinology Research Centre |
| publishDate |
2017 |
| url |
https://doaj.org/article/ddec57eac97a47c58a35e8caabf57d19 |
| work_keys_str_mv |
AT aleksandervictorovichdoga comparisonofefficacyandsafetyofthecombinedlasertreatmenttechnologyversusconventionallaserphotocoagulationindiabeticmacularedemamanagement AT galinafedorovnakachalina comparisonofefficacyandsafetyofthecombinedlasertreatmenttechnologyversusconventionallaserphotocoagulationindiabeticmacularedemamanagement AT elenakonstantinovnapedanova comparisonofefficacyandsafetyofthecombinedlasertreatmenttechnologyversusconventionallaserphotocoagulationindiabeticmacularedemamanagement AT dmitryanatolievichburyakov comparisonofefficacyandsafetyofthecombinedlasertreatmenttechnologyversusconventionallaserphotocoagulationindiabeticmacularedemamanagement |
| _version_ |
1718429559234232320 |