«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE

Abstract. Using ELISA and immunoblotting we have monitored the activity of “free” antibodies against virus structure proteins in the sera of HIV–infected patients at the stage of the developing humoral immune response. Further, a comparative assessment of “free” and “bound” antibodies frequencies in...

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Autores principales:	G. A. Rjazanova, V. P. Kocksin, R. V. Khamzina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hiv-1 antibodies immune complex Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ddedc3adc5cb4f8c98b38b62bca5a61b
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spelling	oai:doaj.org-article:ddedc3adc5cb4f8c98b38b62bca5a61b2021-11-18T08:03:41Z«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE1563-06252313-741X10.15789/1563-0625-2005-1-73-76https://doaj.org/article/ddedc3adc5cb4f8c98b38b62bca5a61b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/430https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Using ELISA and immunoblotting we have monitored the activity of “free” antibodies against virus structure proteins in the sera of HIV–infected patients at the stage of the developing humoral immune response. Further, a comparative assessment of “free” and “bound” antibodies frequencies in the sera of HIV–infection patients at early stage of the disease has been made. We have obtained two fractions of circulating immune complex (CIC1 and CIC2) using precipitation in polyethylenglycol.We have determined, that antibodies against virus proteins coded by gag, pot and env genes formed immune complex dissociating under +60°C.Using non parametric criterion for z–signs. We have shown significant differences between the frequency on antibodies against virus structure proteins in sera and the presence of these antibodies in immune complexes. (Med. Immunol., 2005, vol.7, № 1, pp. 73576)G. A. RjazanovaV. P. KocksinR. V. KhamzinaSPb RAACIarticlehiv-1antibodiesimmune complexImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 73-76 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv-1 antibodies immune complex Immunologic diseases. Allergy RC581-607
spellingShingle	hiv-1 antibodies immune complex Immunologic diseases. Allergy RC581-607 G. A. Rjazanova V. P. Kocksin R. V. Khamzina «FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
description	Abstract. Using ELISA and immunoblotting we have monitored the activity of “free” antibodies against virus structure proteins in the sera of HIV–infected patients at the stage of the developing humoral immune response. Further, a comparative assessment of “free” and “bound” antibodies frequencies in the sera of HIV–infection patients at early stage of the disease has been made. We have obtained two fractions of circulating immune complex (CIC1 and CIC2) using precipitation in polyethylenglycol.We have determined, that antibodies against virus proteins coded by gag, pot and env genes formed immune complex dissociating under +60°C.Using non parametric criterion for z–signs. We have shown significant differences between the frequency on antibodies against virus structure proteins in sera and the presence of these antibodies in immune complexes. (Med. Immunol., 2005, vol.7, № 1, pp. 73576)
format	article
author	G. A. Rjazanova V. P. Kocksin R. V. Khamzina
author_facet	G. A. Rjazanova V. P. Kocksin R. V. Khamzina
author_sort	G. A. Rjazanova
title	«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
title_short	«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
title_full	«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
title_fullStr	«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
title_full_unstemmed	«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE
title_sort	«free» and «bound» antibodies against hiv–1 structure proteins at early stage of the disease
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ddedc3adc5cb4f8c98b38b62bca5a61b
work_keys_str_mv	AT garjazanova freeandboundantibodiesagainsthiv1structureproteinsatearlystageofthedisease AT vpkocksin freeandboundantibodiesagainsthiv1structureproteinsatearlystageofthedisease AT rvkhamzina freeandboundantibodiesagainsthiv1structureproteinsatearlystageofthedisease
_version_	1718422512599040000

«FREE» AND «BOUND» ANTIBODIES AGAINST HIV–1 STRUCTURE PROTEINS AT EARLY STAGE OF THE DISEASE

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