Clinical application of mesenchymal stem cells in rheumatic diseases

Abstract Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yajing Wang, Dan Ma, Zewen Wu, Baoqi Yang, Rong Li, Xingxing Zhao, Helin Yang, Liyun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mesenchymal stem cells Rheumatic diseases Clinical application Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/ddef958ca57642a5a546a32fdb1061e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ddef958ca57642a5a546a32fdb1061e7
record_format	dspace
spelling	oai:doaj.org-article:ddef958ca57642a5a546a32fdb1061e72021-11-14T12:08:04ZClinical application of mesenchymal stem cells in rheumatic diseases10.1186/s13287-021-02635-91757-6512https://doaj.org/article/ddef958ca57642a5a546a32fdb1061e72021-11-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02635-9https://doaj.org/toc/1757-6512Abstract Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro. Under specific conditions, MSCs can differentiate into osteoblasts, neuron-like cells, adipocytes and muscle cells and so on, therefore, have a great application value in cell replacement therapy and tissue repair. In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases. This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.Yajing WangDan MaZewen WuBaoqi YangRong LiXingxing ZhaoHelin YangLiyun ZhangBMCarticleMesenchymal stem cellsRheumatic diseasesClinical applicationMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesenchymal stem cells Rheumatic diseases Clinical application Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Mesenchymal stem cells Rheumatic diseases Clinical application Medicine (General) R5-920 Biochemistry QD415-436 Yajing Wang Dan Ma Zewen Wu Baoqi Yang Rong Li Xingxing Zhao Helin Yang Liyun Zhang Clinical application of mesenchymal stem cells in rheumatic diseases
description	Abstract Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro. Under specific conditions, MSCs can differentiate into osteoblasts, neuron-like cells, adipocytes and muscle cells and so on, therefore, have a great application value in cell replacement therapy and tissue repair. In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases. This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.
format	article
author	Yajing Wang Dan Ma Zewen Wu Baoqi Yang Rong Li Xingxing Zhao Helin Yang Liyun Zhang
author_facet	Yajing Wang Dan Ma Zewen Wu Baoqi Yang Rong Li Xingxing Zhao Helin Yang Liyun Zhang
author_sort	Yajing Wang
title	Clinical application of mesenchymal stem cells in rheumatic diseases
title_short	Clinical application of mesenchymal stem cells in rheumatic diseases
title_full	Clinical application of mesenchymal stem cells in rheumatic diseases
title_fullStr	Clinical application of mesenchymal stem cells in rheumatic diseases
title_full_unstemmed	Clinical application of mesenchymal stem cells in rheumatic diseases
title_sort	clinical application of mesenchymal stem cells in rheumatic diseases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ddef958ca57642a5a546a32fdb1061e7
work_keys_str_mv	AT yajingwang clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT danma clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT zewenwu clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT baoqiyang clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT rongli clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT xingxingzhao clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT helinyang clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases AT liyunzhang clinicalapplicationofmesenchymalstemcellsinrheumaticdiseases
_version_	1718429437716856832

Clinical application of mesenchymal stem cells in rheumatic diseases

Ejemplares similares