Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory sites, coining this a ‘mezzanine response’ distinc...

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Autores principales:	Robyn M. Sutherland, Sarah L. Londrigan, Jamie L. Brady, Emma M. Carrington, Julia M. Marchingo, Susanne Heinzel, Philip D. Hodgkin, Kate L. Graham, Thomas W. Kay, Yifan Zhan, Andrew M. Lew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ddf258470896415aaf2e07fd3e6bba40
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spelling	oai:doaj.org-article:ddf258470896415aaf2e07fd3e6bba402021-12-02T15:39:02ZCognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ10.1038/ncomms148092041-1723https://doaj.org/article/ddf258470896415aaf2e07fd3e6bba402017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14809https://doaj.org/toc/2041-1723Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory sites, coining this a ‘mezzanine response’ distinct from primary and secondary responses associated with professional APCs.Robyn M. SutherlandSarah L. LondriganJamie L. BradyEmma M. CarringtonJulia M. MarchingoSusanne HeinzelPhilip D. HodgkinKate L. GrahamThomas W. KayYifan ZhanAndrew M. LewNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robyn M. Sutherland Sarah L. Londrigan Jamie L. Brady Emma M. Carrington Julia M. Marchingo Susanne Heinzel Philip D. Hodgkin Kate L. Graham Thomas W. Kay Yifan Zhan Andrew M. Lew Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
description	Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory sites, coining this a ‘mezzanine response’ distinct from primary and secondary responses associated with professional APCs.
format	article
author	Robyn M. Sutherland Sarah L. Londrigan Jamie L. Brady Emma M. Carrington Julia M. Marchingo Susanne Heinzel Philip D. Hodgkin Kate L. Graham Thomas W. Kay Yifan Zhan Andrew M. Lew
author_facet	Robyn M. Sutherland Sarah L. Londrigan Jamie L. Brady Emma M. Carrington Julia M. Marchingo Susanne Heinzel Philip D. Hodgkin Kate L. Graham Thomas W. Kay Yifan Zhan Andrew M. Lew
author_sort	Robyn M. Sutherland
title	Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
title_short	Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
title_full	Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
title_fullStr	Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
title_full_unstemmed	Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ
title_sort	cognate antigen engagement on parenchymal cells stimulates cd8+ t cell proliferation in situ
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ddf258470896415aaf2e07fd3e6bba40
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Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

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