Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

Fengqian Li,1,* Wen Wu,2,* Li Xiang,1 Gan Weng,1 Hua Hong,3 Hong Jiang,4 Jun Qian31Department of Pharmacy, Shanghai Xuhui Dahua Hospital, 2Department of Orthopaedics, Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, 3Key Laboratory for Ultrafine Materials of Minis...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Li FQ, Wu W, Xiang L, Weng G, Hong H, Jiang H, Qian J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/ddf353b58b714e5dae3bdaa1ee578432
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:ddf353b58b714e5dae3bdaa1ee578432
record_format dspace
spelling oai:doaj.org-article:ddf353b58b714e5dae3bdaa1ee5784322021-12-02T01:01:50ZSustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair1178-2013https://doaj.org/article/ddf353b58b714e5dae3bdaa1ee5784322015-06-01T00:00:00Zhttp://www.dovepress.com/sustained-release-of-vh-and-rhbmp-2-from-nanoporous-magnesiumndashzinc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fengqian Li,1,* Wen Wu,2,* Li Xiang,1 Gan Weng,1 Hua Hong,3 Hong Jiang,4 Jun Qian31Department of Pharmacy, Shanghai Xuhui Dahua Hospital, 2Department of Orthopaedics, Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, 4School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of China*Co-first authors contributed equally to this workAbstract: Nanoporous magnesium–zinc–silicon (n-MZS) xerogels with a pore size of ~4 nm, a surface area of 718 cm2/g, and a pore volume of 1.24 cm3/g were synthesized by a sol–gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium–zinc–silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.Keywords: nanoporous xerogels, sustained release, drugs, osteomyelitis, bone regeneration, bactericidal activity, cytocompatibilityLi FQWu WXiang LWeng GHong HJiang HQian JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4071-4080 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Li FQ
Wu W
Xiang L
Weng G
Hong H
Jiang H
Qian J
Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
description Fengqian Li,1,* Wen Wu,2,* Li Xiang,1 Gan Weng,1 Hua Hong,3 Hong Jiang,4 Jun Qian31Department of Pharmacy, Shanghai Xuhui Dahua Hospital, 2Department of Orthopaedics, Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, 4School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of China*Co-first authors contributed equally to this workAbstract: Nanoporous magnesium–zinc–silicon (n-MZS) xerogels with a pore size of ~4 nm, a surface area of 718 cm2/g, and a pore volume of 1.24 cm3/g were synthesized by a sol–gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium–zinc–silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.Keywords: nanoporous xerogels, sustained release, drugs, osteomyelitis, bone regeneration, bactericidal activity, cytocompatibility
format article
author Li FQ
Wu W
Xiang L
Weng G
Hong H
Jiang H
Qian J
author_facet Li FQ
Wu W
Xiang L
Weng G
Hong H
Jiang H
Qian J
author_sort Li FQ
title Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
title_short Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
title_full Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
title_fullStr Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
title_full_unstemmed Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
title_sort sustained release of vh and rhbmp-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/ddf353b58b714e5dae3bdaa1ee578432
work_keys_str_mv AT lifq sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT wuw sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT xiangl sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT wengg sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT hongh sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT jiangh sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
AT qianj sustainedreleaseofvhandrhbmp2fromnanoporousmagnesiumndashzincndashsiliconxerogelsforosteomyelitistreatmentandbonerepair
_version_ 1718403349304311808

Ejemplares similares