The N-terminal dimerization is required for TDP-43 splicing activity
Abstract TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-terminal domain (NTD) and nuclear localization signal (NLS) (i.e., TDP-35) results in mislocalization to cytoplasm and formation of inclusions. However, how the NTD functions in TDP-43 activity and p...
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Autores principales: | Lei-Lei Jiang, Wei Xue, Jun-Ye Hong, Jun-Ting Zhang, Min-Jun Li, Shao-Ning Yu, Jian-Hua He, Hong-Yu Hu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/ddf3e5d75a5b43d2a2fe776a5771ce0c |
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