Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

In the era of personalized medicine, fetal sex-specific research is of utmost importance for comprehending the mechanisms governing pregnancy and pregnancy-related complications. In recent times, noncoding RNAs (ncRNAs) have gained increasing attention as critical players in gene regulation and dise...

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Autores principales:	Rosaria Varì, Beatrice Scazzocchio, Tiziana Filardi, Anna Citarella, Maria Bellenghi, Roberta Masella, Carmela Santangelo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ncRNA miRNA pregnancy complications placenta embryo fetal sex Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ddf4241eae2d447dadfe648593a3d90c
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spelling	oai:doaj.org-article:ddf4241eae2d447dadfe648593a3d90c2021-11-25T16:48:23ZSignificance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications10.3390/biomedicines91115092227-9059https://doaj.org/article/ddf4241eae2d447dadfe648593a3d90c2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1509https://doaj.org/toc/2227-9059In the era of personalized medicine, fetal sex-specific research is of utmost importance for comprehending the mechanisms governing pregnancy and pregnancy-related complications. In recent times, noncoding RNAs (ncRNAs) have gained increasing attention as critical players in gene regulation and disease pathogenesis, and as candidate biomarkers in human diseases as well. Different types of ncRNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in every step of pregnancy progression, although studies taking into consideration fetal sex as a central variable are still limited. To date, most of the available data have been obtained investigating sex-specific placental miRNA expression. Several studies revealed that miRNAs regulate the (patho)-physiological processes in a sexually dimorphic manner, ensuring normal fetal development, successful pregnancy, and susceptibility to diseases. Moreover, the observation that ncRNA profiles differ according to cells, tissues, and developmental stages of pregnancy, along with the complex interactions among different types of ncRNAs in regulating gene expression, strongly indicates that more studies are needed to understand the role of sex-specific ncRNA in pregnancy and associated disorders.Rosaria VarìBeatrice ScazzocchioTiziana FilardiAnna CitarellaMaria BellenghiRoberta MasellaCarmela SantangeloMDPI AGarticlencRNAmiRNApregnancy complicationsplacentaembryofetal sexBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1509, p 1509 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncRNA miRNA pregnancy complications placenta embryo fetal sex Biology (General) QH301-705.5
spellingShingle	ncRNA miRNA pregnancy complications placenta embryo fetal sex Biology (General) QH301-705.5 Rosaria Varì Beatrice Scazzocchio Tiziana Filardi Anna Citarella Maria Bellenghi Roberta Masella Carmela Santangelo Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
description	In the era of personalized medicine, fetal sex-specific research is of utmost importance for comprehending the mechanisms governing pregnancy and pregnancy-related complications. In recent times, noncoding RNAs (ncRNAs) have gained increasing attention as critical players in gene regulation and disease pathogenesis, and as candidate biomarkers in human diseases as well. Different types of ncRNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in every step of pregnancy progression, although studies taking into consideration fetal sex as a central variable are still limited. To date, most of the available data have been obtained investigating sex-specific placental miRNA expression. Several studies revealed that miRNAs regulate the (patho)-physiological processes in a sexually dimorphic manner, ensuring normal fetal development, successful pregnancy, and susceptibility to diseases. Moreover, the observation that ncRNA profiles differ according to cells, tissues, and developmental stages of pregnancy, along with the complex interactions among different types of ncRNAs in regulating gene expression, strongly indicates that more studies are needed to understand the role of sex-specific ncRNA in pregnancy and associated disorders.
format	article
author	Rosaria Varì Beatrice Scazzocchio Tiziana Filardi Anna Citarella Maria Bellenghi Roberta Masella Carmela Santangelo
author_facet	Rosaria Varì Beatrice Scazzocchio Tiziana Filardi Anna Citarella Maria Bellenghi Roberta Masella Carmela Santangelo
author_sort	Rosaria Varì
title	Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
title_short	Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
title_full	Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
title_fullStr	Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
title_full_unstemmed	Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications
title_sort	significance of sex differences in ncrnas expression and function in pregnancy and related complications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ddf4241eae2d447dadfe648593a3d90c
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Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

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