Postoperative cognitive functions in patients with benign intracranial lesions

Abstract The aim of this study was to assess pre- and postoperative cognitive functions in patients who underwent surgery for benign intracranial lesions. In total, 58 patients (21 men, 37 women, mean age 51.6 years [range 24–76 years]) with benign intracranial lesions (including benign tumors and v...

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Autores principales:	Stefanie Bette, Julia M. Ruhland, Benedikt Wiestler, Melanie Barz, Bernhard Meyer, Claus Zimmer, Yu-Mi Ryang, Florian Ringel, Jens Gempt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ddf6e6f4205845fc8546d3d6e65dd4f9
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spelling	oai:doaj.org-article:ddf6e6f4205845fc8546d3d6e65dd4f92021-12-02T17:32:57ZPostoperative cognitive functions in patients with benign intracranial lesions10.1038/s41598-021-88061-62045-2322https://doaj.org/article/ddf6e6f4205845fc8546d3d6e65dd4f92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88061-6https://doaj.org/toc/2045-2322Abstract The aim of this study was to assess pre- and postoperative cognitive functions in patients who underwent surgery for benign intracranial lesions. In total, 58 patients (21 men, 37 women, mean age 51.6 years [range 24–76 years]) with benign intracranial lesions (including benign tumors and vascular lesions) and neuralgia of the trigeminal nerve were included in this prospective study. Extensive cognitive testing was used to categorize attention, memory, and executive functions. Mood and pain were assessed preoperatively (t0, mean 3.7 days before surgery), immediately after surgery/during inpatient stay (t1, mean 7.6 days after surgery), and at first outpatient check-up (t2, mean 99.5 days after surgery). All 58 patients were tested at t0 and t1, but at t2 only 24 patients were available at t2. The data were categorized as improvement/stable condition or deterioration and shown as percentages. The pre- and postoperative values of BDI-II and mood were compared by the Wilcoxon test for paired samples. Binary logistic regression analyses were performed to identify parameters influencing cognition in the subgroup of meningioma patients. Immediately after surgery (t1), the percentage of patients with improvement/stable condition was > 50% in all categories in the majority of subtests (attention: 12/14 subtests, memory: 11/13 subtests, executive functions: 6/9 subtests). Similar results were shown at t2. Mood and pain did not change significantly after surgery. Factors like age, Karnofsky performance status, and tumor volume were not shown as significant influencing factors for cognitive functions in meningioma patients. The results of this study suggest that—in contrast to neuroepithelial tumors—cognitive functions do not deteriorate after surgery of benign intracranial lesions. Further studies are necessary to evaluate the results of this study.Stefanie BetteJulia M. RuhlandBenedikt WiestlerMelanie BarzBernhard MeyerClaus ZimmerYu-Mi RyangFlorian RingelJens GemptNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefanie Bette Julia M. Ruhland Benedikt Wiestler Melanie Barz Bernhard Meyer Claus Zimmer Yu-Mi Ryang Florian Ringel Jens Gempt Postoperative cognitive functions in patients with benign intracranial lesions
description	Abstract The aim of this study was to assess pre- and postoperative cognitive functions in patients who underwent surgery for benign intracranial lesions. In total, 58 patients (21 men, 37 women, mean age 51.6 years [range 24–76 years]) with benign intracranial lesions (including benign tumors and vascular lesions) and neuralgia of the trigeminal nerve were included in this prospective study. Extensive cognitive testing was used to categorize attention, memory, and executive functions. Mood and pain were assessed preoperatively (t0, mean 3.7 days before surgery), immediately after surgery/during inpatient stay (t1, mean 7.6 days after surgery), and at first outpatient check-up (t2, mean 99.5 days after surgery). All 58 patients were tested at t0 and t1, but at t2 only 24 patients were available at t2. The data were categorized as improvement/stable condition or deterioration and shown as percentages. The pre- and postoperative values of BDI-II and mood were compared by the Wilcoxon test for paired samples. Binary logistic regression analyses were performed to identify parameters influencing cognition in the subgroup of meningioma patients. Immediately after surgery (t1), the percentage of patients with improvement/stable condition was > 50% in all categories in the majority of subtests (attention: 12/14 subtests, memory: 11/13 subtests, executive functions: 6/9 subtests). Similar results were shown at t2. Mood and pain did not change significantly after surgery. Factors like age, Karnofsky performance status, and tumor volume were not shown as significant influencing factors for cognitive functions in meningioma patients. The results of this study suggest that—in contrast to neuroepithelial tumors—cognitive functions do not deteriorate after surgery of benign intracranial lesions. Further studies are necessary to evaluate the results of this study.
format	article
author	Stefanie Bette Julia M. Ruhland Benedikt Wiestler Melanie Barz Bernhard Meyer Claus Zimmer Yu-Mi Ryang Florian Ringel Jens Gempt
author_facet	Stefanie Bette Julia M. Ruhland Benedikt Wiestler Melanie Barz Bernhard Meyer Claus Zimmer Yu-Mi Ryang Florian Ringel Jens Gempt
author_sort	Stefanie Bette
title	Postoperative cognitive functions in patients with benign intracranial lesions
title_short	Postoperative cognitive functions in patients with benign intracranial lesions
title_full	Postoperative cognitive functions in patients with benign intracranial lesions
title_fullStr	Postoperative cognitive functions in patients with benign intracranial lesions
title_full_unstemmed	Postoperative cognitive functions in patients with benign intracranial lesions
title_sort	postoperative cognitive functions in patients with benign intracranial lesions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ddf6e6f4205845fc8546d3d6e65dd4f9
work_keys_str_mv	AT stefaniebette postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT juliamruhland postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT benediktwiestler postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT melaniebarz postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT bernhardmeyer postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT clauszimmer postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT yumiryang postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT florianringel postoperativecognitivefunctionsinpatientswithbenignintracraniallesions AT jensgempt postoperativecognitivefunctionsinpatientswithbenignintracraniallesions
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Postoperative cognitive functions in patients with benign intracranial lesions

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