A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in...

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Autores principales: Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ddf85b9902a447478bc6eb1f3abe22df
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spelling oai:doaj.org-article:ddf85b9902a447478bc6eb1f3abe22df2021-12-02T15:33:31ZA Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration10.1038/s41467-019-14029-w2041-1723https://doaj.org/article/ddf85b9902a447478bc6eb1f3abe22df2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14029-whttps://doaj.org/toc/2041-1723Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in response to injury.Yuki MatsushitaMizuki NagataKenneth M. KozloffJoshua D. WelchKoji MizuhashiNicha TokavanichShawn A. HallettDaniel C. LinkTakashi NagasawaWanida OnoNoriaki OnoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuki Matsushita
Mizuki Nagata
Kenneth M. Kozloff
Joshua D. Welch
Koji Mizuhashi
Nicha Tokavanich
Shawn A. Hallett
Daniel C. Link
Takashi Nagasawa
Wanida Ono
Noriaki Ono
A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
description Bone marrow stromal cells (BMSCs) lining sinusoidal blood vessels are mesenchymal cells whose function is critical for the skeleton. Here the authors show that quiescent CXCL12-expressing BMSCs can convert into a skeletal stem cell-like state, and differentiate into cortical bone osteoblasts only in response to injury.
format article
author Yuki Matsushita
Mizuki Nagata
Kenneth M. Kozloff
Joshua D. Welch
Koji Mizuhashi
Nicha Tokavanich
Shawn A. Hallett
Daniel C. Link
Takashi Nagasawa
Wanida Ono
Noriaki Ono
author_facet Yuki Matsushita
Mizuki Nagata
Kenneth M. Kozloff
Joshua D. Welch
Koji Mizuhashi
Nicha Tokavanich
Shawn A. Hallett
Daniel C. Link
Takashi Nagasawa
Wanida Ono
Noriaki Ono
author_sort Yuki Matsushita
title A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
title_short A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
title_full A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
title_fullStr A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
title_full_unstemmed A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
title_sort wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ddf85b9902a447478bc6eb1f3abe22df
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