Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles
Nanodrug self-assembled by amphiphilic small molecules were proved to be important resource of medicine. In this study, a nanodrug of hydrophobic doxorubicin (DOX)linked to lactose (Lac) via pH sensitive acylhydrazide bond was used as a carrier to entrap the hydrophobic doxorubicin to form drug-load...
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Elsevier
2021
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oai:doaj.org-article:ddfb347e08ba4b3b854c6b4f75cffa5f2021-11-20T04:55:43ZIntelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles0264-127510.1016/j.matdes.2021.110230https://doaj.org/article/ddfb347e08ba4b3b854c6b4f75cffa5f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0264127521007851https://doaj.org/toc/0264-1275Nanodrug self-assembled by amphiphilic small molecules were proved to be important resource of medicine. In this study, a nanodrug of hydrophobic doxorubicin (DOX)linked to lactose (Lac) via pH sensitive acylhydrazide bond was used as a carrier to entrap the hydrophobic doxorubicin to form drug-loaded nanoparticles (Lac-DOX/DOX). We hope the increased drug to ligand ratio will improve the targeting efficiency of the nanodrug, which leads to better toxicity. The in vitro and in vivo experiments proved that with this nanodrug of Lac-DOX/DOX, we achieved active targeting, passive targeting and physical–chemical targeting through asialoglycoprotein receptor(ASGPR) on liver cancer cells, EPR effect of tumor tissue and acidic tumor microenvironment. This multiple combination can inhibit hepatoma cell proliferation, promote apoptosis, induce immunogenic cell death (ICD) and improve the anti-tumor effect.Chunxiao GaoYuanyuan MaDeyue YanLianzhen ChenWei YuanJie MaElsevierarticleNanomicellesHepatoma targetLactoseDoxorubicinMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110230- (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Nanomicelles Hepatoma target Lactose Doxorubicin Materials of engineering and construction. Mechanics of materials TA401-492 |
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Nanomicelles Hepatoma target Lactose Doxorubicin Materials of engineering and construction. Mechanics of materials TA401-492 Chunxiao Gao Yuanyuan Ma Deyue Yan Lianzhen Chen Wei Yuan Jie Ma Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| description |
Nanodrug self-assembled by amphiphilic small molecules were proved to be important resource of medicine. In this study, a nanodrug of hydrophobic doxorubicin (DOX)linked to lactose (Lac) via pH sensitive acylhydrazide bond was used as a carrier to entrap the hydrophobic doxorubicin to form drug-loaded nanoparticles (Lac-DOX/DOX). We hope the increased drug to ligand ratio will improve the targeting efficiency of the nanodrug, which leads to better toxicity. The in vitro and in vivo experiments proved that with this nanodrug of Lac-DOX/DOX, we achieved active targeting, passive targeting and physical–chemical targeting through asialoglycoprotein receptor(ASGPR) on liver cancer cells, EPR effect of tumor tissue and acidic tumor microenvironment. This multiple combination can inhibit hepatoma cell proliferation, promote apoptosis, induce immunogenic cell death (ICD) and improve the anti-tumor effect. |
| format |
article |
| author |
Chunxiao Gao Yuanyuan Ma Deyue Yan Lianzhen Chen Wei Yuan Jie Ma |
| author_facet |
Chunxiao Gao Yuanyuan Ma Deyue Yan Lianzhen Chen Wei Yuan Jie Ma |
| author_sort |
Chunxiao Gao |
| title |
Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| title_short |
Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| title_full |
Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| title_fullStr |
Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| title_full_unstemmed |
Intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| title_sort |
intelligently responsive amphiphilic small molecule loaded with doxorubicin to form highly effective anti-hepatocarcinoma nanomicelles |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/ddfb347e08ba4b3b854c6b4f75cffa5f |
| work_keys_str_mv |
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| _version_ |
1718419745940701184 |