Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.
DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary r...
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oai:doaj.org-article:ddfd00b63e7e452f9a300c2d098793a92021-11-18T06:51:53ZIncreased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.1932-620310.1371/journal.pone.0020580https://doaj.org/article/ddfd00b63e7e452f9a300c2d098793a92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698230/?tool=EBIhttps://doaj.org/toc/1932-6203DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling. Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia.Satu MassinenMarie-Estelle HokkanenHans MatssonKristiina TammimiesIsabel Tapia-PáezVanina Dahlström-HeuserJuha Kuja-PanulaJan BurghoornKristian E JeppssonPeter SwobodaMyriam Peyrard-JanvidRune ToftgårdEero CastrénJuha KerePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20580 (2011) |
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Medicine R Science Q Satu Massinen Marie-Estelle Hokkanen Hans Matsson Kristiina Tammimies Isabel Tapia-Páez Vanina Dahlström-Heuser Juha Kuja-Panula Jan Burghoorn Kristian E Jeppsson Peter Swoboda Myriam Peyrard-Janvid Rune Toftgård Eero Castrén Juha Kere Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| description |
DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling. Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia. |
| format |
article |
| author |
Satu Massinen Marie-Estelle Hokkanen Hans Matsson Kristiina Tammimies Isabel Tapia-Páez Vanina Dahlström-Heuser Juha Kuja-Panula Jan Burghoorn Kristian E Jeppsson Peter Swoboda Myriam Peyrard-Janvid Rune Toftgård Eero Castrén Juha Kere |
| author_facet |
Satu Massinen Marie-Estelle Hokkanen Hans Matsson Kristiina Tammimies Isabel Tapia-Páez Vanina Dahlström-Heuser Juha Kuja-Panula Jan Burghoorn Kristian E Jeppsson Peter Swoboda Myriam Peyrard-Janvid Rune Toftgård Eero Castrén Juha Kere |
| author_sort |
Satu Massinen |
| title |
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| title_short |
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| title_full |
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| title_fullStr |
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| title_full_unstemmed |
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. |
| title_sort |
increased expression of the dyslexia candidate gene dcdc2 affects length and signaling of primary cilia in neurons. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/ddfd00b63e7e452f9a300c2d098793a9 |
| work_keys_str_mv |
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