Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.

DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary r...

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Autores principales: Satu Massinen, Marie-Estelle Hokkanen, Hans Matsson, Kristiina Tammimies, Isabel Tapia-Páez, Vanina Dahlström-Heuser, Juha Kuja-Panula, Jan Burghoorn, Kristian E Jeppsson, Peter Swoboda, Myriam Peyrard-Janvid, Rune Toftgård, Eero Castrén, Juha Kere
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ddfd00b63e7e452f9a300c2d098793a9
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