Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients

Xin Zhou,* Mei Luo,* Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoxia YuDepartment of Endocrino...

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Autores principales:	Zhou X, Luo M, Zhou S, Cheng Z, Chen Z, Yu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes mellitus obesity plasma alarin level insulin resistance blood sugar blood lipids insulin. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ddfef130e306429399d99d46de7ca360
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spelling	oai:doaj.org-article:ddfef130e306429399d99d46de7ca3602021-12-02T14:08:53ZPlasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients1178-7007https://doaj.org/article/ddfef130e306429399d99d46de7ca3602021-01-01T00:00:00Zhttps://www.dovepress.com/plasma-alarin-level-and-its-influencing-factors-in-obese-newly-diagnos-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xin Zhou,* Mei Luo,* Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoxia YuDepartment of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of ChinaTel/Fax +86 2363842760Email yudoctor789@163.comObjective: To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance.Methods: From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β) and other clinical data were collected and analyzed.Results: BMI, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM obese group increased sequentially, and high-density lipoprotein-cholesterol (HDL-L) and HOMA-β decreased sequentially (P< 0.05). Correlation analysis results showed that plasma alarin levels in T2DM patients were positively correlated with waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P< 0.05), and negatively correlated with HDL-C and HOMA-β (P < 0.05), and the correlation coefficient of T2DM obese group was significantly higher than that of T2DM non-obese group (P< 0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, HbA1c, HOMA-β, and HOMA-IR were independent factors related to plasma alarin levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient of the T2DM obese group was significantly higher than that of the T2DM non-obese group (P < 0.05).Conclusion: Plasma alarin levels increase in newly diagnosed T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-β and HOMA-IR, and may be involved in development of T2DM.Keywords: type 2 diabetes mellitus, obesity, plasma alarin level, insulin resistance, blood sugar, blood lipids, insulinZhou XLuo MZhou SCheng ZChen ZYu XDove Medical Pressarticletype 2 diabetes mellitusobesityplasma alarin levelinsulin resistanceblood sugarblood lipidsinsulin.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 379-385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus obesity plasma alarin level insulin resistance blood sugar blood lipids insulin. Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes mellitus obesity plasma alarin level insulin resistance blood sugar blood lipids insulin. Specialties of internal medicine RC581-951 Zhou X Luo M Zhou S Cheng Z Chen Z Yu X Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
description	Xin Zhou,* Mei Luo,* Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoxia YuDepartment of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of ChinaTel/Fax +86 2363842760Email yudoctor789@163.comObjective: To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance.Methods: From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β) and other clinical data were collected and analyzed.Results: BMI, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM obese group increased sequentially, and high-density lipoprotein-cholesterol (HDL-L) and HOMA-β decreased sequentially (P< 0.05). Correlation analysis results showed that plasma alarin levels in T2DM patients were positively correlated with waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P< 0.05), and negatively correlated with HDL-C and HOMA-β (P < 0.05), and the correlation coefficient of T2DM obese group was significantly higher than that of T2DM non-obese group (P< 0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, HbA1c, HOMA-β, and HOMA-IR were independent factors related to plasma alarin levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient of the T2DM obese group was significantly higher than that of the T2DM non-obese group (P < 0.05).Conclusion: Plasma alarin levels increase in newly diagnosed T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-β and HOMA-IR, and may be involved in development of T2DM.Keywords: type 2 diabetes mellitus, obesity, plasma alarin level, insulin resistance, blood sugar, blood lipids, insulin
format	article
author	Zhou X Luo M Zhou S Cheng Z Chen Z Yu X
author_facet	Zhou X Luo M Zhou S Cheng Z Chen Z Yu X
author_sort	Zhou X
title	Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
title_short	Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
title_full	Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
title_fullStr	Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
title_full_unstemmed	Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
title_sort	plasma alarin level and its influencing factors in obese newly diagnosed type 2 diabetes patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ddfef130e306429399d99d46de7ca360
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Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients

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