Allergic diseases in infancy: I - Epidemiology and current interpretation
Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8t...
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2021
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oai:doaj.org-article:de027bf420574b38b88e560d883b1de62021-11-14T04:31:38ZAllergic diseases in infancy: I - Epidemiology and current interpretation1939-455110.1016/j.waojou.2021.100591https://doaj.org/article/de027bf420574b38b88e560d883b1de62021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1939455121000855https://doaj.org/toc/1939-4551Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8th Human Milk Workshop. Information from the fields of pediatrics, epidemiology, biology, microbiology, and immunology are summarized to establish a framework describing potential avenues for the prevention of allergic diseases in the future. Results: Several environmental circumstances are linked to the development of allergic diseases. While cesarean section is increasing the risk of allergies, early childhood exposure to a farm environment has a protective effect. From their analysis, nutritive and non-nutritive factors influencing the allergy risk in later life have been identified. The effect of breastfeeding on food allergy development is non-univocal. Human milk components including immunoglobulins, cytokines, and prebiotics have been indicated as important for allergy prevention. Conclusion: Many factors linked to the western lifestyle have been associated with the development of allergic diseases. This suggests several theories that may serve as a basis for new protective interventions. While it is indubitable that mother's milk protects from infectious diseases, its role in the prevention of allergic diseases is to be elucidated.Isabella Annesi-MaesanoManja FleddermannMathias HornefErika von MutiusOliver PabstMonika SchaubeckAlessandro FiocchiElsevierarticleAllergyAllergy preventionFarm effectHygiene hypothesisImmunologic diseases. AllergyRC581-607ENWorld Allergy Organization Journal, Vol 14, Iss 11, Pp 100591- (2021) |
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Allergy Allergy prevention Farm effect Hygiene hypothesis Immunologic diseases. Allergy RC581-607 |
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Allergy Allergy prevention Farm effect Hygiene hypothesis Immunologic diseases. Allergy RC581-607 Isabella Annesi-Maesano Manja Fleddermann Mathias Hornef Erika von Mutius Oliver Pabst Monika Schaubeck Alessandro Fiocchi Allergic diseases in infancy: I - Epidemiology and current interpretation |
description |
Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8th Human Milk Workshop. Information from the fields of pediatrics, epidemiology, biology, microbiology, and immunology are summarized to establish a framework describing potential avenues for the prevention of allergic diseases in the future. Results: Several environmental circumstances are linked to the development of allergic diseases. While cesarean section is increasing the risk of allergies, early childhood exposure to a farm environment has a protective effect. From their analysis, nutritive and non-nutritive factors influencing the allergy risk in later life have been identified. The effect of breastfeeding on food allergy development is non-univocal. Human milk components including immunoglobulins, cytokines, and prebiotics have been indicated as important for allergy prevention. Conclusion: Many factors linked to the western lifestyle have been associated with the development of allergic diseases. This suggests several theories that may serve as a basis for new protective interventions. While it is indubitable that mother's milk protects from infectious diseases, its role in the prevention of allergic diseases is to be elucidated. |
format |
article |
author |
Isabella Annesi-Maesano Manja Fleddermann Mathias Hornef Erika von Mutius Oliver Pabst Monika Schaubeck Alessandro Fiocchi |
author_facet |
Isabella Annesi-Maesano Manja Fleddermann Mathias Hornef Erika von Mutius Oliver Pabst Monika Schaubeck Alessandro Fiocchi |
author_sort |
Isabella Annesi-Maesano |
title |
Allergic diseases in infancy: I - Epidemiology and current interpretation |
title_short |
Allergic diseases in infancy: I - Epidemiology and current interpretation |
title_full |
Allergic diseases in infancy: I - Epidemiology and current interpretation |
title_fullStr |
Allergic diseases in infancy: I - Epidemiology and current interpretation |
title_full_unstemmed |
Allergic diseases in infancy: I - Epidemiology and current interpretation |
title_sort |
allergic diseases in infancy: i - epidemiology and current interpretation |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doaj.org/article/de027bf420574b38b88e560d883b1de6 |
work_keys_str_mv |
AT isabellaannesimaesano allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT manjafleddermann allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT mathiashornef allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT erikavonmutius allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT oliverpabst allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT monikaschaubeck allergicdiseasesininfancyiepidemiologyandcurrentinterpretation AT alessandrofiocchi allergicdiseasesininfancyiepidemiologyandcurrentinterpretation |
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1718429988439457792 |