Allergic diseases in infancy: I - Epidemiology and current interpretation

Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8t...

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Autores principales: Isabella Annesi-Maesano, Manja Fleddermann, Mathias Hornef, Erika von Mutius, Oliver Pabst, Monika Schaubeck, Alessandro Fiocchi
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Lenguaje:EN
Publicado: Elsevier 2021
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spelling oai:doaj.org-article:de027bf420574b38b88e560d883b1de62021-11-14T04:31:38ZAllergic diseases in infancy: I - Epidemiology and current interpretation1939-455110.1016/j.waojou.2021.100591https://doaj.org/article/de027bf420574b38b88e560d883b1de62021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1939455121000855https://doaj.org/toc/1939-4551Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8th Human Milk Workshop. Information from the fields of pediatrics, epidemiology, biology, microbiology, and immunology are summarized to establish a framework describing potential avenues for the prevention of allergic diseases in the future. Results: Several environmental circumstances are linked to the development of allergic diseases. While cesarean section is increasing the risk of allergies, early childhood exposure to a farm environment has a protective effect. From their analysis, nutritive and non-nutritive factors influencing the allergy risk in later life have been identified. The effect of breastfeeding on food allergy development is non-univocal. Human milk components including immunoglobulins, cytokines, and prebiotics have been indicated as important for allergy prevention. Conclusion: Many factors linked to the western lifestyle have been associated with the development of allergic diseases. This suggests several theories that may serve as a basis for new protective interventions. While it is indubitable that mother's milk protects from infectious diseases, its role in the prevention of allergic diseases is to be elucidated.Isabella Annesi-MaesanoManja FleddermannMathias HornefErika von MutiusOliver PabstMonika SchaubeckAlessandro FiocchiElsevierarticleAllergyAllergy preventionFarm effectHygiene hypothesisImmunologic diseases. AllergyRC581-607ENWorld Allergy Organization Journal, Vol 14, Iss 11, Pp 100591- (2021)
institution DOAJ
collection DOAJ
language EN
topic Allergy
Allergy prevention
Farm effect
Hygiene hypothesis
Immunologic diseases. Allergy
RC581-607
spellingShingle Allergy
Allergy prevention
Farm effect
Hygiene hypothesis
Immunologic diseases. Allergy
RC581-607
Isabella Annesi-Maesano
Manja Fleddermann
Mathias Hornef
Erika von Mutius
Oliver Pabst
Monika Schaubeck
Alessandro Fiocchi
Allergic diseases in infancy: I - Epidemiology and current interpretation
description Objective: Among non-communicable diseases, the prevalence of allergic diseases has increased significantly in the new millennium. The increase of allergic diseases is linked to the changing environment of infants. Methods: This narrative review summarizes the discussions and conclusions from the 8th Human Milk Workshop. Information from the fields of pediatrics, epidemiology, biology, microbiology, and immunology are summarized to establish a framework describing potential avenues for the prevention of allergic diseases in the future. Results: Several environmental circumstances are linked to the development of allergic diseases. While cesarean section is increasing the risk of allergies, early childhood exposure to a farm environment has a protective effect. From their analysis, nutritive and non-nutritive factors influencing the allergy risk in later life have been identified. The effect of breastfeeding on food allergy development is non-univocal. Human milk components including immunoglobulins, cytokines, and prebiotics have been indicated as important for allergy prevention. Conclusion: Many factors linked to the western lifestyle have been associated with the development of allergic diseases. This suggests several theories that may serve as a basis for new protective interventions. While it is indubitable that mother's milk protects from infectious diseases, its role in the prevention of allergic diseases is to be elucidated.
format article
author Isabella Annesi-Maesano
Manja Fleddermann
Mathias Hornef
Erika von Mutius
Oliver Pabst
Monika Schaubeck
Alessandro Fiocchi
author_facet Isabella Annesi-Maesano
Manja Fleddermann
Mathias Hornef
Erika von Mutius
Oliver Pabst
Monika Schaubeck
Alessandro Fiocchi
author_sort Isabella Annesi-Maesano
title Allergic diseases in infancy: I - Epidemiology and current interpretation
title_short Allergic diseases in infancy: I - Epidemiology and current interpretation
title_full Allergic diseases in infancy: I - Epidemiology and current interpretation
title_fullStr Allergic diseases in infancy: I - Epidemiology and current interpretation
title_full_unstemmed Allergic diseases in infancy: I - Epidemiology and current interpretation
title_sort allergic diseases in infancy: i - epidemiology and current interpretation
publisher Elsevier
publishDate 2021
url https://doaj.org/article/de027bf420574b38b88e560d883b1de6
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AT erikavonmutius allergicdiseasesininfancyiepidemiologyandcurrentinterpretation
AT oliverpabst allergicdiseasesininfancyiepidemiologyandcurrentinterpretation
AT monikaschaubeck allergicdiseasesininfancyiepidemiologyandcurrentinterpretation
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