Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study

BACKGROUND AND OBJECTIVE: Identification of cancer risk factors in the community and prevention planning in high-risk groups can be helpful in cancer prevention program. Hence, the aim of this study was to investigate the relationship between reproductive factors and breast cancer in the Tabari popu...

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Autores principales:	M Moosazadeh, R Roohi, A Hedayatizadeh-Omran, M Kheradmand, Gh Janbabai, R Khazaei, R Alizadeh-Navaei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	reproductive factor risk factors breast cancer persian cohort tabari cohort. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/de03d577a39f438a87a729d8408f1f77
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spelling	oai:doaj.org-article:de03d577a39f438a87a729d8408f1f772021-11-09T10:15:54ZRelationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study1561-41072251-7170https://doaj.org/article/de03d577a39f438a87a729d8408f1f772020-03-01T00:00:00Zhttp://jbums.org/article-1-8630-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Identification of cancer risk factors in the community and prevention planning in high-risk groups can be helpful in cancer prevention program. Hence, the aim of this study was to investigate the relationship between reproductive factors and breast cancer in the Tabari population-based cohort study in a case-control design. METHODS: This case-control study was performed on the enrolment phase of the Tabari population-based cohort. Patients with breast cancer were considered as case group (51) and non-cancerous individuals (204) as a control group. The two groups were matched based on age category and oral contraceptive pill (OCP) intake. The studied variables included breast cancer history, demographic and reproductive factors. FINDINGS: Mean age of first pregnancy (22.76±4.99 vs. 20.8±4.16, p=0.005), mean age at first birth (23.57±4.94 vs. 21.66±4.07, p=0.006) and age of marriage (22.24±5.75 vs. 19.54±4.92, p=0.001) in the case group were significantly higher than the control group and the number of pregnancies (3.76±2.22 vs. 4.67±2.76, p=0.032) and number of children (3.27±1.97 vs. 4.16±2.44, p=0.019) in the case group was significantly less than the control group. According to multivariate analysis, the odds of incidence of breast cancer in people with first pregnancy over 22 years was 2.76 times more than (p= 0.027) those with first pregnancy age below 22 years. CONCLUSION: “Age at first full-term pregnancy” is one of the major risk factors for breast cancer in the area.M MoosazadehR RoohiA Hedayatizadeh-OmranM KheradmandGh JanbabaiR KhazaeiR Alizadeh-NavaeiBabol University of Medical Sciencesarticlereproductive factorrisk factorsbreast cancerpersian cohorttabari cohort.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 65-71 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	reproductive factor risk factors breast cancer persian cohort tabari cohort. Medicine R Medicine (General) R5-920
spellingShingle	reproductive factor risk factors breast cancer persian cohort tabari cohort. Medicine R Medicine (General) R5-920 M Moosazadeh R Roohi A Hedayatizadeh-Omran M Kheradmand Gh Janbabai R Khazaei R Alizadeh-Navaei Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
description	BACKGROUND AND OBJECTIVE: Identification of cancer risk factors in the community and prevention planning in high-risk groups can be helpful in cancer prevention program. Hence, the aim of this study was to investigate the relationship between reproductive factors and breast cancer in the Tabari population-based cohort study in a case-control design. METHODS: This case-control study was performed on the enrolment phase of the Tabari population-based cohort. Patients with breast cancer were considered as case group (51) and non-cancerous individuals (204) as a control group. The two groups were matched based on age category and oral contraceptive pill (OCP) intake. The studied variables included breast cancer history, demographic and reproductive factors. FINDINGS: Mean age of first pregnancy (22.76±4.99 vs. 20.8±4.16, p=0.005), mean age at first birth (23.57±4.94 vs. 21.66±4.07, p=0.006) and age of marriage (22.24±5.75 vs. 19.54±4.92, p=0.001) in the case group were significantly higher than the control group and the number of pregnancies (3.76±2.22 vs. 4.67±2.76, p=0.032) and number of children (3.27±1.97 vs. 4.16±2.44, p=0.019) in the case group was significantly less than the control group. According to multivariate analysis, the odds of incidence of breast cancer in people with first pregnancy over 22 years was 2.76 times more than (p= 0.027) those with first pregnancy age below 22 years. CONCLUSION: “Age at first full-term pregnancy” is one of the major risk factors for breast cancer in the area.
format	article
author	M Moosazadeh R Roohi A Hedayatizadeh-Omran M Kheradmand Gh Janbabai R Khazaei R Alizadeh-Navaei
author_facet	M Moosazadeh R Roohi A Hedayatizadeh-Omran M Kheradmand Gh Janbabai R Khazaei R Alizadeh-Navaei
author_sort	M Moosazadeh
title	Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
title_short	Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
title_full	Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
title_fullStr	Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
title_full_unstemmed	Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study
title_sort	relationship between reproductive factor and breast cancer in mazandaran cohort: a case-control study
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/de03d577a39f438a87a729d8408f1f77
work_keys_str_mv	AT mmoosazadeh relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT rroohi relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT ahedayatizadehomran relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT mkheradmand relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT ghjanbabai relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT rkhazaei relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy AT ralizadehnavaei relationshipbetweenreproductivefactorandbreastcancerinmazandarancohortacasecontrolstudy
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Relationship between Reproductive Factor and Breast Cancer in Mazandaran Cohort: A Case-Control Study

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